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ETS1 Human shRNA Plasmid Kit (Locus ID 2113)

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SKU
TL313153
ETS1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "ETS1 or NM_001143820"

Specifications
Specifications
Product Data
Locus ID 2113
Synonyms c-ets-1; ETS-1; EWSR2; p54
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components ETS1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 2113). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001143820, NM_001162422, NM_001330451, NM_005238, NM_005238.1, NM_005238.2, NM_005238.3, NM_001143820.1, NM_001162422.1, BC017314, BM468663, NM_001143820.2, NM_005238.4
UniProt ID P14921
Summary This gene encodes a member of the ETS family of transcription factors, which are defined by the presence of a conserved ETS DNA-binding domain that recognizes the core consensus DNA sequence GGAA/T in target genes. These proteins function either as transcriptional activators or repressors of numerous genes, and are involved in stem cell development, cell senescence and death, and tumorigenesis. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.provided by RefSeq, Jul 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

ETS1 Suppresses Tumorigenesis of Human Breast Cancer via Trans-Activation of Canonical Tumor Suppressor Genes
Kim, Lee, Verma et al
Front Oncol (2020) 10, 642 DOI: 10.3389/fonc.2020.00642
Cited by 23
AI Summary: OriGene products, including control shRNA (TR30021), ETS1-targeted shRNA (TL313153), and Human cDNA clone ETS1 (RC215203L2), were used in this study to knock down or overexpress ETS1 in breast cancer cell lines, enabling the investigation of ETS1’s role as a tumor suppressor.
Snippet: Gene knockdown was accomplished using the shRNA system with control shRNA (TR30021) or ETS1 targeted shRNA (TL313153) (OriGene Technologies, Rockville, MD). … Gene overexpression was accomplished using Human cDNA clone ETS1 (RC215203L2) (OriGene Technologies, Rockville, MD). MCF-7 cells were infected with lentiviral particle encoding hETS1. …
FigureFigureFigure
Showing 1-1 of 1 papers.
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