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HAT1 Human shRNA Plasmid Kit (Locus ID 8520)

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SKU
TL312517
HAT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "HAT1 or NM_001033085"

Specifications
Specifications
Product Data
Locus ID 8520
Synonyms histone acetyltransferase 1; KAT1
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components HAT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 8520). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001033085, NM_003642, NR_027862, NM_001033085.1, NM_003642.2, NM_003642.3, BC063003, BC063003.1, BC018682, BC045673
UniProt ID O14929
Summary The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. provided by RefSeq, Jun 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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Acetyl-Click Screening Platform Identifies Small-Molecule Inhibitors of Histone Acetyltransferase 1 (HAT1)
Gaddameedi, Chou, Geller et al
J Med Chem (2023) 66 (8), 5774-5801 DOI: 10.1021/acs.jmedchem.3c00039
Cited by 11
AI Summary: OriGene’s HAT1-targeting lentiviral shRNAs (OriGene #TL312517) were used to knock down HAT1 expression in A549 cells for tumor studies, enabling the assessment of HAT1's role in cancer cell growth and response to small-molecule inhibitors.
Snippet: For tumor studies, A549 cells were infected with three lentiviral shRNAs targeting the human HAT1 mRNA (Origene # TL312517). 6 to 8 week old NSG female mice (Jackson Labs #005557) were shaved, then 500,000
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
Gruber, Geller, Lipchik et al
Mol Cell (2019) 75 (4), 711-724.e5 DOI: 10.1016/j.molcel.2019.05.034
Cited by 109
AI Summary: In this study, OriGene’s HAT1 shRNA (TL313105) and HAT1 overexpression plasmid (RC203307) were used to manipulate HAT1 expression levels, enabling the authors to investigate HAT1’s role in coordinating histone H4 production and acetylation.
Figure
HAT1 Coordinates Histone Production and Acetylation via H4 Promoter Binding
Gruber, Geller, Lipchik et al
Molecular Cell (2019) 75 (4), 711-724.e5 DOI: 10.1016/j.molcel.2019.05.034
AI Summary: OriGene products, including Human HAT1 cDNA in lentiviral vector (Cat# RC209571L1), Human HAT1 lentiviral shRNAs (Cat# TL312517), and Lentiviral control shRNA (human) in pGFP-C-shLenti (Cat# TR30021), were used in this study to manipulate HAT1 expression in human cells, enabling the authors to elucidate HAT1's role in histone gene regulation and cell proliferation.
Snippet: Skip to article;Human HAT1 cDNA in lentiviral vector (pGFP-CshLenti) Origene Cat# RC209571L1 Human HAT1 lentiviral shRNAs Origene Cat# TL312517 Mouse Hat1 lentivrial shRNAs (pLKO-puro-IPTG3xLacO): TRCN0000231310, TRCN0000039275, TRCN0000231307 Sigma-Aldrich custom Lentiviral control shRNA (mouse) Sigma-Aldrich SHC332V Lentiviral control shRNA (human) in pGFP-C-shLenti Origene TR30021
Showing 1-3 of 3 papers.
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