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HPD Human shRNA Plasmid Kit (Locus ID 3242)

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SKU
TL312348
HPD - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "HPD or NM_001171993"

Specifications
Specifications
Product Data
Locus ID 3242
Synonyms 4-HPPD; 4HPPD; GLOD3; HPPDASE; PPD
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components HPD - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3242). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001171993, NM_002150, NM_002150.1, NM_001171993.1, BC024287, BC024287.1, BC014790
UniProt ID P32754
Summary The protein encoded by this gene is an enzyme in the catabolic pathway of tyrosine. The encoded protein catalyzes the conversion of 4-hydroxyphenylpyruvate to homogentisate. Defects in this gene are a cause of tyrosinemia type 3 (TYRO3) and hawkinsinuria (HAWK). Two transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Jan 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Inhibition of BCAT1-mediated cytosolic leucine metabolism regulates Th17 responses via the mTORC1-HIF1α pathway
Kang, Song, Lee et al
Exp Mol Med (2024) 56 (8), 1776-1790 DOI: 10.1038/s12276-024-01286-z
Cited by 38
AI Summary: OriGene’s human shRNA plasmids (Cat# TL314498 for BCATc, TL312348 for HPD, TL304319 for HPDL, and TR30021 for control) were used to silence target genes in human CD4+ memory T cells, enabling the study of how BCAT1-mediated leucine metabolism regulates Th17 responses in this paper.
Snippet: To silence BCATc, HPD, and HPDL expression in human CD4+ memory T cells, we used BCATc, HPD, or HPDL human shRNA plasmids containing the GFP reporter gene (Origene, Rockville, MD;Cat# TL314498 for BCATc, TL312348 for HPD, TL304319 for HPDL, and TR30021 for control). Lentivirus was produced by transfection of the lentiviral vector, along with psPAX2
FigureFigureFigure
Showing 1-1 of 1 papers.
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