HSF1 Human shRNA Plasmid Kit (Locus ID 3297)
SKU
TL312318
HSF1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 3297 |
|---|---|
| Synonyms | HSTF1 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | HSF1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3297). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | NM_005526, NM_005526.1, NM_005526.2, NM_005526.3, BC014638, BC014638.1, NM_005526.4 |
| UniProt ID | Q00613 |
| Summary | The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. provided by RefSeq, Jul 2017 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
C/EBPβ is a key transcription factor for APOE and preferentially mediates ApoE4 expression in Alzheimer's disease
Xia, Wang, Zhang et al
Mol Psychiatry (2020)
Xia, Wang, Zhang et al
Mol Psychiatry (2020)
Cited by 66
AI Summary: OriGene products contributed shRNA-expressing lentiviruses targeting HSF-1, C/EBPα, C/EBPβ, and ApoE, which were used to manipulate gene expression and investigate the regulatory role of C/EBPβ in APOE expression and Alzheimer's disease pathology.
Snippet: The apolipoprotein E ε4 (APOE4) allele is a major genetic risk factor for Alzheimer's disease (AD), and its protein product, ApoE4, exerts its deleterious effects mainly by influencing amyloid-β (Aβ) and Tau (neurofibrillary tangles, NFTs) deposition in the brain. However;The shRNA expressing lentivirus for HSF-1, C/EBPα, C/EBPβ, and ApoE were ordered from OriGene Technologies, Inc. …
C/EBPβ regulates delta-secretase expression and mediates pathogenesis in mouse models of Alzheimer's disease
Wang, Gong, Liu et al
Nat Commun (2018) 9 (1), 1784 DOI: 10.1038/s41467-018-04120-z
Wang, Gong, Liu et al
Nat Commun (2018) 9 (1), 1784 DOI: 10.1038/s41467-018-04120-z
AI Summary: OriGene’s shRNA lentiviruses targeting HSF1, C/EBPα, and C/EBPβ were used to manipulate gene expression in this study, enabling the authors to investigate the regulatory role of C/EBPβ in delta-secretase expression and Alzheimer’s disease pathogenesis.
Snippet: t from Santa Cruz. The overexpression lentivirus (pFCGW-GFP) was from the viral vector core (VVC) of Emory University. The shRNA expressing lentivirus for HSF1, C/EBPα, and C/EBPβ were ordered from OriGene Technologies, Inc. (Rockville, MD). HEK293 transfection was performed using Lipofectamine 2000 (Invitrogen). The lentiviruses used in neuron infection and brain injection were packaged in VVC
Showing 1-2 of 2 papers.
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