IL6 Human shRNA Plasmid Kit (Locus ID 3569)
SKU
TL312162
IL6 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
$1,013.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 3569 |
|---|---|
| Synonyms | BSF-2; BSF2; CDF; HGF; HSF; IFN-beta-2; IFNB2; IL-6 |
| Vector | pGFP-C-shLenti |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Lentiviral plasmids |
| Components | IL6 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 3569). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free. |
| RefSeq | BC015511, NM_000600, NM_001318095, NM_000600.1, NM_000600.2, NM_000600.3, NM_000600.4, NM_000600.5 |
| UniProt ID | P05231 |
| Summary | This gene encodes a cytokine that functions in inflammation and the maturation of B cells. In addition, the encoded protein has been shown to be an endogenous pyrogen capable of inducing fever in people with autoimmune diseases or infections. The protein is primarily produced at sites of acute and chronic inflammation, where it is secreted into the serum and induces a transcriptional inflammatory response through interleukin 6 receptor, alpha. The functioning of this gene is implicated in a wide variety of inflammation-associated disease states, including suspectibility to diabetes mellitus and systemic juvenile rheumatoid arthritis. Elevated levels of the encoded protein have been found in virus infections, including COVID-19 (disease caused by SARS-CoV-2). provided by RefSeq, Aug 2020 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
Antitumor and Anti-Invasive Effect of Apigenin on Human Breast Carcinoma through Suppression of IL-6 Expression
Lee, Jung, Moon et al
Int J Mol Sci (2019) 20 (13) DOI: 10.3390/ijms20133143
Lee, Jung, Moon et al
Int J Mol Sci (2019) 20 (13) DOI: 10.3390/ijms20133143
AI Summary: OriGene’s Human IL-6 shRNA lentivirus plasmid with pGFP vector kit (#TL312162) was used to block IL-6 expression in MDA-MB-231 breast cancer cells, enabling the study of IL-6’s role in tumor progression and the anti-invasive effects of apigenin.
Snippet: Human IL-6 shRNA lentivirus plasmid with pGFP vector kit (#TL312162, Origene, Rockville, MD, USA) was used for blocking IL-6 expression in MDA-MB-231 cells. Briefly, cells were seeded at a density of 5 × 105 cells/well in a six-well plate and incubated overnight. After incubation, the supernatant was aspirated, and the cells were treated with the mixture of shRNA plasmid-Lipofectamine 2000 reagent (Invitrogen, Carlsbad, CA, USA) for 5 h at 37 °C. …
Showing 1-1 of 1 papers.
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