MDM2 Human shRNA Plasmid Kit (Locus ID 4193)

SKU TL311529

MDM2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 4193
• Synonyms: hdm2; HDMX; MGC5370; MGC71221
• Vector: pGFP-C-shLenti
• E. coli Selection: Chloramphenicol (34 ug/ml)
• Format: Lentiviral plasmids
• Components: MDM2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 4193). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
• RefSeq: NM_001145336, NM_001145337, NM_001145339, NM_001145340, NM_001278462, NM_002392, NM_006878, NM_006879, NM_006880, NM_006881, NM_006882, NM_002392.1, NM_002392.2, NM_002392.3, NM_002392.4, NM_002392.5, NM_001145337.1, NM_001145337.2, NM_001145339.1, NM_001145339.2, NM_001145340.1, NM_001145340.2, NM_001278462.1, NM_001145336.1, NM_006878.2, NM_006879.2, NM_006881.2, NM_006882.2, BC006795, BC065505, BC107414, BC148522, BC152384, BC152390, BC153117, NM_001367990, NM_001145337.3, NM_001145340.3, NM_001278462.2
• UniProt ID: Q00987
• Summary: This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient