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MDM2 Mouse Monoclonal Antibody [Clone ID: OTI1E6]

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SKU
TA801812
MDM2 mouse monoclonal antibody, clone OTI1E6 (formerly 1E6)
Size:
100 ul 30 ul
Formulation:
Standard Carrier-free
Conjugation:
Unconjugated Biotin HRP
  $447.00
In Stock*
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View other "MDM2 or NM_002392" antibodies

Specifications
Specifications
Product Data
Clone Name OTI1E6
Application IHC, WB
Recommended Dilution WB 1:2000, IHC 1:150
Reactivity Human
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Human recombinant protein fragment corresponding to amino acids 119-438 of human MDM2 (NP_002383) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 55.8 kDa
Gene Name MDM2 proto-oncogene
Database Link
Background This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues. provided by RefSeq, Jul 2008
Synonyms ACTFS; hdm2; HDMX
Reference Data
Protein Categories Cancer: Brain and CNS, Cancer: Gynecologic, Cancer: Sarcoma, Intracellular Proteins
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Endocytosis, Glioma, Melanoma, p53 signaling pathway, Pathways in cancer, Prostate cancer, Ubiquitin mediated proteolysis
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Other "OTI1E6" antibodies (4)
SKU Description Size Price
CF801812 Carrier-free (BSA/glycerol-free) MDM2 mouse monoclonal antibody, clone OTI1E6 (formerly 1E6) 100 ug
$620.00
TA801812AM MDM2 mouse monoclonal antibody,clone 1E6, Biotinylated 100 ul
$509.00
TA801812BM MDM2 mouse monoclonal antibody,clone 1E6, HRP conjugated 100 ul
$509.00
TA801812S MDM2 mouse monoclonal antibody, clone OTI1E6 (formerly 1E6) 30 ul
$200.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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