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RAB7 (RAB7A) Human shRNA Plasmid Kit (Locus ID 7879)

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SKU
TL309983
RAB7A - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "RAB7 or NM_004637"

Specifications
Specifications
Product Data
Locus ID 7879
Synonyms CMT2B; PRO2706; RAB7
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components RAB7A - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7879). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_004637, NM_004637.1, NM_004637.2, NM_004637.3, NM_004637.4, NM_004637.5, BC008721, BC008721.2, BC013728, BC014200, NM_004637.6
UniProt ID P51149
Summary RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Murine leukemia virus glycosylated Gag reduces murine SERINC5 protein expression at steady-state levels via endosome/lysosome pathway to counteract the SERINC5 antiretroviral activity
Li, Ahmad, Shi et al
J. Virol. (2018) 93 (2) DOI: 10.1128/JVI.01651-18
AI Summary: In this study, OriGene products—including pCMV6-AP-1μ1 (RC202366), pCMV-mSer1-FLAG (MR207184), pCMV-mSer2-FLAG (MR207238), pCMV-mSer3-FLAG (MR207539), pCMV-mSer5-FLAG (MR207354), and pGFP-C-shLenti shRNA vectors targeting AP-2σ, Rab5a, Rab7a, and Rab11a—were used to express and manipulate SERINC proteins and endosomal pathway components, enabling the authors to elucidate how MLV glycosylated Gag downregulates SERINC5 via the endosome/lysosome pathway.
Snippet: … Murine leukemia virus glycosylated Gag reduces murine SERINC5 protein expression at 1 steady-state levels via endosome/lysosome pathway to counteract the SERINC5 antiretrovi- 2 ral activity 3 Sunan Li1#, Iqbal;The following vectors were ordered from OriGene: pCMV6 -AP - 1 1 (RC202366), 373 pCMV - mSer 1 -FLAG (MR207184), pCMV - mSer 2 -FLAG (MR207238), pCMV - mSer 3 -FLAG 374 (MR207539), pCMV - mSer5 -FLAG (MR207354), and pGFP - C -shLenti vectors expressing 375 shRNAs against AP - 2  (TL306655), Rab5a (TL309987), Rab7a (TL309983), and Rab11a 376 (TL310015)
HIV-1 Nef antagonizes SERINC5 restriction by downregulation of SERINC5 via the endosome/lysosome system
Shi, Xiong, Zhou et al
J. Virol. (2018)
AI Summary: OriGene products contributed to this study by providing the pCMV6-AP-1μ1 expression vector (RC202366) and pGFP-C-shLenti vectors expressing shRNAs against AP-2σ1 (TL306655), Rab5a (TL309987), Rab7a (TL309983), and Rab11a (TL310015), which were used to manipulate the expression of key endosomal trafficking proteins and assess their roles in Nef-mediated SERINC5 downregulation.
Snippet: V5 vector. The following vectors were ordered from OriGene: pCMV6-AP-1μ1 (RC202366) 389 and pGFP-C-shLenti vectors expressing shRNAs against AP-2σ1 (TL306655), Rab5a 390 (TL309987), Rab7a (TL309983), and Rab11a (TL310015). 391
Showing 1-2 of 2 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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