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RUNX3 Human shRNA Plasmid Kit (Locus ID 864)

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SKU
TL309682
RUNX3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 864
Synonyms AML2; CBFA3; PEBP2aC
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components RUNX3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 864). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC013362, NM_001031680, NM_001320672, NM_004350, NM_001031680.1, NM_001031680.2, NM_004350.1, NM_004350.2, BC013362.2, NM_004350.3
UniProt ID Q13761
Summary This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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file-alt Citations

IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression
Fang, Cao, Mu et al
JCI Insight (2022) 7 (12) DOI: 10.1172/jci.insight.157509
Cited by 15
AI Summary: OriGene’s shRUNX3 lentiviral vector (catalog TL309682) was used in this study to silence RUNX3 in human T cells, enabling the authors to investigate the role of RUNX3 in regulating CD39 expression and T cell function.
Snippet: … shRUNX3 lentiviral vector (Origene, catalog TL309682) was used to silence RUNX3 in human T cells. Lentivirus was produced by transfection of the lentiviral vector, along with psPAX2 and pMD2.G (Plasmid 12260 and 12259, Addgene);Human GATA3 or RUNX3 was inserted into lentivector (pCDH-GFP-Em-CD513B-1, System Biosciences) using the following primers: hRUNX3_enzy_F: 5′ AACTAGCTAGCatggcatcgaacagcatcttcg 3′ and hRUNX3_enzy_R: 5′ ATACGCGGATCCtcagtagggccgccacac 3′;and hGATA3_enzy_F: 5′ AACTAGCTAGCatggaggtgacggcgga 3′ and hGATA3_enzy_R: 5′ ATAAGAATGCGGCCGCctaacccatggcggtgacc 3′. shRUNX3 lentiviral vector (Origene, catalog TL309682) was used to silence RUNX3 in human T cells. …
The cell-surface 5'-nucleotidase CD73 defines a functional T memory cell subset that declines with age
Fang, Cao, Zhu et al
Cell Rep (2021) 37 (6), 109981 DOI: 10.1016/j.celrep.2021.109981
Cited by 48
AI Summary: In this study, OriGene’s RUNX2/GFP lentivector (Cat#: RC212884L4) and human shRNA plasmids targeting RUNX3 (Cat#: TL309682) and RUNX2 (Cat#: TL309683) were used to manipulate the expression of these transcription factors in human T cells, enabling investigation of their roles in regulating CD73 expression and memory T cell function.
Snippet: oned into a commercial lentivector containing a GFP reporter gene (pCDH-GFP-Em-CD513B-1 from System Biosciences). To overexpress RUNX2 in human T cells, we purchased commercial RUNX2/GFP lentivector (Origene, Cat#: RC212884L4). To knockdown RUNX3 or RUNX2 in human T cells, we used RUNX3 or RUNX2 human shRNA plasmid containing GFP reporter gene (Origene, Cat#: TL309682 for RUNX3;Cat#: TL309683 for
FigureFigureFigure
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation
Cao, Fang, Gould et al
J. Clin. Invest. (2020) 130 (7), 3422-3436 DOI: 10.1172/JCI132417
Cited by 1
AI Summary: OriGene’s RUNX3 shRNA lentiviral vector (TL309682) was used in this study to knock down RUNX3 expression in human T cells, enabling the authors to investigate the role of RUNX3 in regulating T follicular helper cell generation.
Snippet: … For overexpression studies, ENTPD1, BCL6, or RUNX3 was subcloned into pHAGE-CMV-IRES-ZsGreen-W (plasmid 26532, Addgene). Lentiviral vector containing RUNX3 shRNA was obtained from OriGene (TL309682). …
Showing 1-3 of 3 papers.
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