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SIX1 Human shRNA Plasmid Kit (Locus ID 6495)

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SKU
TL309429
SIX1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "SIX1 or NM_005982"

Specifications
Specifications
Product Data
Locus ID 6495
Synonyms BOS3; DFNA23; TIP39
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components SIX1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6495). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_005982, NM_005982.1, NM_005982.2, NM_005982.3, BC008874, BC008874.2, NM_005982.4
UniProt ID Q15475
Summary The protein encoded by this gene is a homeobox protein that is similar to the Drosophila 'sine oculis' gene product. This gene is found in a cluster of related genes on chromosome 14 and is thought to be involved in limb development. Defects in this gene are a cause of autosomal dominant deafness type 23 (DFNA23) and branchiootic syndrome type 3 (BOS3). provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

SIX1 reduces the expression of PTEN via activating PI3K/AKT signal to promote cell proliferation and tumorigenesis in osteosarcoma
Yu, Zhang, Li et al
Biomed. Pharmacother. (2018) 105, 10-17 DOI: 10.1016/j.biopha.2018.04.028
AI Summary: OriGene products, specifically the SIX1 expression plasmid (SC123830) and shRNA-SIX1 (SR321496), were used in this study to manipulate SIX1 levels in osteosarcoma cell lines, enabling the investigation of SIX1's role in regulating PTEN expression and promoting tumor progression.
Snippet: SR321496) and their negative vector all were purchased from OriGene (USA), and were transfected into U2OS and SAOS2 cells with Opti-MEM containing Lipofectamine 2000 (Invitrogen, Carlsbad, CA, USA) SC123830, OriGene, USA) and shRNA-SIX1 (No
Showing 1-1 of 1 papers.
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