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TRF2 (TERF2) Human shRNA Plasmid Kit (Locus ID 7014)

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SKU
TL308880
TERF2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
2 Weeks*

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Other products for "TRF2 or NM_005652"

Specifications
Specifications
Product Data
Locus ID 7014
Synonyms TRBF2; TRF2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components TERF2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 7014). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC024890, NM_005652, NM_005652.1, NM_005652.2, NM_005652.3, NM_005652.4, BC024890.1
UniProt ID Q15554
Summary This gene encodes a telomere specific protein, TERF2, which is a component of the telomere nucleoprotein complex. This protein is present at telomeres in metaphase of the cell cycle, is a second negative regulator of telomere length and plays a key role in the protective activity of telomeres. While having similar telomere binding activity and domain organization, TERF2 differs from TERF1 in that its N terminus is basic rather than acidic. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Telomeres control human telomerase (TERT) expression through non-telomeric TRF2
Sengupta, Vinayagamurthy, Soni et al
Elife (2025) 14 DOI: 10.7554/eLife.104045
AI Summary: In this study, OriGene’s TRF2 shRNA (catalog number TL308880) was used to specifically knock down TRF2 expression, enabling the authors to investigate the role of TRF2 in telomere length-dependent regulation of TERT transcription.
Snippet: Recombinant DNA Reagent TRF2 shRNA origene TL308880 Plasmid Recombinant DNA Reagent pSpCas9(BB)–2A-Puro (PX459) V2.0 Addgene #62988 RRID:Addgene_62988 Plasmid
FigureFigureFigure
Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment
Mukherjee, Dutta, Singh et al
Elife (2024) 13 DOI: 10.7554/eLife.95106
AI Summary: OriGene products contributed to this study by providing the pCMV6-myc-DDK(FLAG)-TRF2 vector (RC223601) for TRF2 overexpression and TRF2 shRNA plasmid (TL308880) for TRF2 knockdown, enabling the authors to investigate the role of TRF2 in telomere length-dependent regulation of IL1R1 and immune signalling in cancer.
Snippet: l (1:100) Antibody Anti-mouse IgG (mouse polyclonal) Millipore (Millipore 12–371) isotype control (1:100) Recombinant DNA reagent pCMV6-myc-DDK(FLAG)-TRF2 vector (TRF2 WT) origene RC223601 Plasmid Recombinant DNA reagent TRF2 shRNA origene TL308880 Plasmid Recombinant DNA reagent dCAS9-VP64-GFP Addgene 61422 Plasmid Recombinant
FigureFigureFigure
Telomere repeat-binding factor 2 binds extensively to extra-telomeric G-quadruplexes and regulates the epigenetic status of several gene promoters
Mukherjee, Sharma, Bagri et al
J. Biol. Chem. (2019) 294 (47), 17709-17722 DOI: 10.1074/jbc.RA119.008687
AI Summary: OriGene contributed to this study by providing the pCMV6-myc-DDK (FLAG)-TRF2 expression vector (RC223601), which was used to investigate the role of TRF2 in binding to extra-telomeric G-quadruplexes and regulating gene promoter epigenetic status.
Snippet: was received as a gift from Dr Giraud Panis, CNRS, France. The pCMV6-myc-DDK( FLAG)- TRF2 vector was procured from Origene (RC223601). The mutants delB and delM constructs used in the study have been previously reported(19). TRF2 shRNA was procured
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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