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CD70 Human shRNA Plasmid Kit (Locus ID 970)

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SKU
TL308721
CD70 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "CD70 or NM_001252"

Specifications
Specifications
Product Data
Locus ID 970
Synonyms CD27-L; CD27L; CD27LG; LPFS3; TNFSF7; TNLG8A
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components CD70 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 970). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001252, NM_001330332, NM_001252.1, NM_001252.2, NM_001252.3, NM_001252.4, BC000725, BC000725.2, NM_001252.5
UniProt ID P32970
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Breast cancer stem cells characterized by CD70 expression preferentially metastasize to the lungs
Liu, Yin, Yi et al
Breast Cancer (2018)
AI Summary: OriGene’s pGFP-C-shLenti plasmid was used in this study to produce lentiviruses for CD70 gene knockdown and control shRNA, enabling the researchers to investigate the functional role of CD70 in breast cancer stem cell metastasis.
Snippet: not blinded. Lentivirus production and gene knockdown shRNA constructs against CD70 and a non-effective 29-mer shRNA cassette (termed control) were cloned into the pGFP-C-shLenti plasmid (OriGene). Lentivirus was
Showing 1-1 of 1 papers.
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