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CRBN Human shRNA Plasmid Kit (Locus ID 51185)

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SKU
TL305228
CRBN - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "CRBN or NM_001173482"

Specifications
Specifications
Product Data
Locus ID 51185
Synonyms MRT2; MRT2A
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components CRBN - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 51185). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001173482, NM_016302, NM_016302.1, NM_016302.2, NM_016302.3, NM_001173482.1, BC067811, BC067811.1, BC017419, BC059171, NM_016302.4
UniProt ID Q96SW2
Summary This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Mar 2010
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling
Shen, Nayak, Neitzel et al
Nat Commun (2021) 12 (1), 5263 DOI: 10.1038/s41467-021-25634-z
Cited by 44
AI Summary: OriGene products, specifically lentiviral shRNA constructs targeting human CRBN (TL305228V #B, TL205228V #D), mouse Crbn (TL503372V #A-D), and a mouse Scramble control (TR30021V), were used in this study to manipulate CRBN expression and investigate its role in Wnt signaling.
Snippet: 021086-11-0005). Lentiviral expressing shRNA targeting human CRBN (#1: TL305228V #B;#2: TL205228V #D), mouse Scramble control (TR30021V), or mouse Crbn (#A-D: TL503372V #A, B, C, D) were purchased (Origene). Cell-based assays HEK293T (HEK), HEK293STF, NIH3T3, and L-WRN cells were purchased from American Type Culture Collection (ATCC) and maintained as recommended. Cells (50–70% confluent) wer
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Showing 1-1 of 1 papers.
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