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EZH2 Human shRNA Plasmid Kit (Locus ID 2146)

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TL304713
EZH2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "EZH2 or NM_001203247"

Specifications
Specifications
Product Data
Locus ID 2146
Synonyms ENX-1; ENX1; EZH2b; KMT6; KMT6A; WVS; WVS2
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components EZH2 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 2146). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001203247, NM_001203248, NM_001203249, NM_004456, NM_152998, NM_004456.1, NM_004456.2, NM_004456.3, NM_004456.4, NM_152998.1, NM_152998.2, NM_001203249.1, NM_001203248.1, NM_001203247.1, BC010858, BC010858.2, BM974565, NM_001203249.2, NM_001203247.2, NM_004456.5, NM_001203248.2, NM_152998.3
UniProt ID Q15910
Summary This gene encodes a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of genes over successive cell generations. This protein associates with the embryonic ectoderm development protein, the VAV1 oncoprotein, and the X-linked nuclear protein. This protein may play a role in the hematopoietic and central nervous systems. Multiple alternatively splcied transcript variants encoding distinct isoforms have been identified for this gene. provided by RefSeq, Feb 2011
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

Tumor-associated antigen PRAME exhibits dualistic functions that are targetable in diffuse large B cell lymphoma
Takata, Chong, Ennishi et al
J Clin Invest (2022) 132 (10) DOI: 10.1172/JCI145343
AI Summary: OriGene’s lenti-GFP-shEZH2 (TL304713) was used to knock down EZH2 expression in lymphoma cells, enabling the study of PRAME’s regulatory interactions and functional consequences in diffuse large B cell lymphoma.
Snippet: … EZH2 knockdown assay. WSU-DLCL2 cells were transduced by lenti-GFP-shEZH2 (OriGene TL304713), and GFP-positive cells were enriched using a FACSAria III cell sorter (BD Biosciences). Western blotting was performed using EZH2 (H.547.3, Thermo Fisher Scientific), PRAME (EPR2033;WSU-DLCL2 cells were transduced by lenti-GFP-shEZH2 (OriGene TL304713), and GFP-positive cells were enriched using a FACSAria III cell sorter (BD Biosciences)
FigureFigureFigure
Long noncoding RNA H19 regulates EZH2 expression by interacting with miR-630 and promotes cell invasion in nasopharyngeal carcinoma
Li, Lin, Yang et al
Biochem. Biophys. Res. Commun. (2016) 473 (4), 913-9 DOI: 10.1016/j.bbrc.2016.03.150
Cited by 84
AI Summary: OriGene’s lentiviral H19-shRNA and EZH2-shRNA vectors were used to knock down H19 and EZH2 expression, enabling the study of their roles in nasopharyngeal carcinoma cell invasion.
Snippet: 2.6. Cell transfection. For knockdown of H19 and EZH2, cells were seeded in 24-well plates and transfected with a lentiviral H19-shRNA or EZH2-shNRA vector (Lv-H19-shRNA or Lv-EZH2-shNRA) (OriGene, Rockville, MD, USA) according to the manufacturer's instructions ... Cite SaveSaving
Sunitinib dose-escalation overcomes transient resistance in clear cell renal cell carcinoma and is associated with epigenetic modifications
Adelaiye, Ciamporcero, Miles et al
Mol. Cancer Ther. (2014)
AI Summary: OriGene Technologies contributed to this study by providing four unique 29mer shRNA constructs and a scrambled negative control shRNA, packaged in a lentiviral GFP vector, which were used to investigate gene function related to sunitinib resistance in clear cell renal cell carcinoma.
Snippet: We used four unique 29mer shRNA constructs, as well as a scrambled negative control non-effective shRNA packaged in a lentiviral green fluorescent protein (GFP) vector which were purchased form Origene Technologies, Inc. (Rockville, MD). ... Cite SaveSaving
Showing 1-3 of 3 papers.
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