OriGene Logo

Customer Login

Checkout as a new customer

Creating an account has many benefits:

  • See order and shipping status
  • Track order history
  • Check out faster
Create an Account

NADPH oxidase 4 (NOX4) Human shRNA Plasmid Kit (Locus ID 50507)

Be the first to review this product
SKU
TL302911
NOX4 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
4 Weeks*

Frequently Bought Together (4)

TA349083 Rabbit Polyclonal Anti-NOX4 Antibody
100 ug
$640.00
EB200002 Lateral flow testing sticks used for the semi-quantitative detection of the lentiviral p24 protein, 20 tests
20 Tests
$450.00
TR30037 Lenti-vpak packaging kit - packaging plasmids and transfection reagent
10 reactions
$720.00
TF81001 TurboFectin Transfection Reagent (1 mL in 1 vial)
1 ml in 1 vial
$530.00

Other products for "NADPH oxidase 4 or NM_001143836"

Specifications
Specifications
Product Data
Locus ID 50507
Synonyms KOX; KOX-1; RENOX
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components NOX4 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 50507). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq BC040105, NM_001143836, NM_001143837, NM_001291926, NM_001291927, NM_001291929, NM_001300995, NM_016931, NR_026571, NR_120406, NM_016931.1, NM_016931.2, NM_016931.3, NM_016931.4, NM_001143836.1, NM_001143836.2, NM_001143837.1, NM_001291926.1, NM_001300995.1, NM_001291929.1, NM_001291927.1, BC040105.1, BC051371
UniProt ID Q9NPH5
Summary This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.provided by RefSeq, Jan 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
Reviews
Write Review
 
 
 
 
 

Be the first to review this product

Please note:
Only reviews with images are eligible for a $20/20€ Amazon gift card.
Reviews without images are eligible for a $10/10€ Amazon gift card.
For more details about the terms and conditions, please visit the promotion page.

Review image
Documents
Resources

file-alt Citations

Cooperative Blockade of CK2 and ATM Kinases Drives Apoptosis in VHL-Deficient Renal Carcinoma Cells through ROS Overproduction
Giacosa, Pillet, Séraudie et al
Cancers (Basel) (2021) 13 (3) DOI: 10.3390/cancers13030576
Cited by 36
AI Summary: In this study, OriGene’s pGFP-C-shLenti containing ShNOX4 (NADPH Oxidase 4) was used to generate lentiviral particles for gene knockdown experiments, enabling the researchers to investigate the role of NOX4 in apoptosis induced by combined CK2 and ATM kinase inhibition in VHL-deficient renal carcinoma cells.
Snippet: Table S1). The pGFP-C-shLenti containing ShNOX4 (NADPH Oxidase 4) from Origene was packaged in lentiviral particles. All compounds were dissolved in dimethyl sulfoxide (DMSO) at a concentration of 10 mM. CX-4945
FigureFigureFigure
Nox4 regulates InsP 3 receptor‐dependent Ca 2+ release into mitochondria to promote cell survival
Beretta, Santos, Molenaar et al
EMBO J (2020)
Cited by 94
AI Summary: OriGene contributed to this study by providing lentiviruses expressing a short hairpin sequence targeting human Nox4 (Cat. no #TL302911V), which were used to knock down Nox4 expression in hiPSC-derived cardiomyocytes to investigate its role in mitochondrial calcium regulation and cell survival.
Snippet: ultiplicity of infection (MOI) of 20. Cells were used 48 h later. Lentiviruses expressing a short hairpin sequence targeted against human Nox4 or a scramble short hairpin sequence were purchased from OriGene (Rockville, MD, USA;Cat. no #TL302911V) and used to infect hiPSC‐CM at an MOI of 10. Cells were used 72 h later. REAL‐TIME RT–PCR Total RNA was isolated using the ReliaPrep RNA Mini
Showing 1-2 of 2 papers.
Powered by BizGenius
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Related Products