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PDCD10 Human shRNA Plasmid Kit (Locus ID 11235)

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SKU
TL302576
PDCD10 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Other products for "PDCD10 or NM_007217"

Specifications
Specifications
Product Data
Locus ID 11235
Synonyms CCM3; TFAR15
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components PDCD10 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 11235). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_007217, NM_145859, NM_145860, NM_007217.1, NM_007217.2, NM_007217.3, NM_145860.1, NM_145859.1, BC002506, BC002506.1, BC016353, NM_007217.4
UniProt ID Q9BUL8
Summary This gene encodes an evolutionarily conserved protein associated with cell apoptosis. The protein interacts with the serine/threonine protein kinase MST4 to modulate the extracellular signal-regulated kinase (ERK) pathway. It also interacts with and is phosphoryated by serine/threonine kinase 25, and is thought to function in a signaling pathway essential for vascular developent. Mutations in this gene are one cause of cerebral cavernous malformations, which are vascular malformations that cause seizures and cerebral hemorrhages. Multiple alternatively spliced variants, encoding the same protein, have been identified. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

PDCD10-Deficient Tumor Cells Reprogram Angiogenesis Through Paracrine Endothelial Activation and GSC-like Plasticity in GBM
Chen, Chen, Wan et al
Cells (2026) 15 (17), 1532-1532 DOI: 10.3390/cells15171532
AI Summary: OriGene products, specifically the lentiviral shRNA vector for PDCD10 knockdown (cat# TL302576) and the empty vector control (cat# TR30021), were used to generate stable PDCD10-deficient and control T98G glioblastoma cell lines, enabling the study of PDCD10’s role in GBM angiogenesis and cellular plasticity.
Snippet: Briefly, the inducible TRIPZ lentiviral shRNA vector targeting human PDCD10 (shPDCD10;Thermo Scientific;clone ID: V2THS_217165) was used to transduce U87 cells (shU87). A second lentiviral shRNA vector (OriGene, Rockville, MD, USA;cat# TL302576) was used for stable knockdown of PDCD10 in T98G cells (shT98G). Empty vector-transduced U87 (evU87;Thermo Scientific, Waltham, MA, USA;cat# RHS4750) and T98G (evT98G;OriGene;cat# TR30021) cells
PDCD10 Is a Key Player in TMZ-Resistance and Tumor Cell Regrowth: Insights into Its Underlying Mechanism in Glioblastoma Cells
Zhu, Kim, Chen et al
Cells (2024) 13 (17), 1442 DOI: 10.3390/cells13171442
Cited by 5
AI Summary: In this study, the OriGene lentiviral shRNA vector for human PDCD10 (cat# TL302576) was used to achieve constitutive knockdown of PDCD10 in glioblastoma cells, enabling the authors to investigate the gene's role in temozolomide resistance and tumor cell regrowth.
Snippet: ector for human PDCD10 (shPDCD10;Thermo Scientific, Waltham, MA, USA, clone ID: V2THS_217165) was used. For constitutive knockdown in T98g cells (shT98g), a lentiviral shRNA vector for human PDCD10 (OriGene, Rockville, MD, USA, cat# TL302576) was used. Red- and green-fluorescence proteins (RFP and GFP, respectively) were used as representative transduction markers. Empty vector transduced cells i
Loss of programmed cell death 10 activates tumor cells and leads to temozolomide-resistance in glioblastoma
Nickel, Wan, Saban et al
J. Neurooncol. (2018)
AI Summary: OriGene products, specifically the shPDCD10:GFP lentiviral shRNA vector (catalog# TL302576) and the empty vector control (catalog# TR30021), were used to achieve constitutive knockdown of PDCD10 in T98g glioblastoma cells, enabling the study of PDCD10’s role in tumor activation and drug resistance.
Snippet: Another lenti- viral shRNA vector for a constitutive knockdown of human PDCD10 (shPDCD10:GFP, catalog# TL302576) and the empty vector (EV:GFP, Catalog# TR30021) (OriGene, Herford, Germany) were applied to T98g cells
Showing 1-3 of 3 papers.
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