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RNF43 Human shRNA Plasmid Kit (Locus ID 54894)

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SKU
TL301933
RNF43 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
In Stock*

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Other products for "RNF43 or NM_001305544"

Specifications
Specifications
Product Data
Locus ID 54894
Synonyms RNF124; SSPCS; URCC
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components RNF43 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 54894). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_001305544, NM_001305545, NM_017763, NM_017763.1, NM_017763.2, NM_017763.3, NM_017763.4, NM_017763.5, BC109028, NM_017763.6
UniProt ID Q68DV7
Summary The protein encoded by this gene is a RING-type E3 ubiquitin ligase and is predicted to contain a transmembrane domain, a protease-associated domain, an ectodomain, and a cytoplasmic RING domain. This protein is thought to negatively regulate Wnt signaling, and expression of this gene results in an increase in ubiquitination of frizzled receptors, an alteration in their subcellular distribution, resulting in reduced surface levels of these receptors. Mutations in this gene have been reported in multiple tumor cells, including colorectal and endometrial cancers. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Mar 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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