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STAT1 Human shRNA Plasmid Kit (Locus ID 6772)

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SKU
TL301349
STAT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 6772
Synonyms CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components STAT1 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6772). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_007315, NM_139266, NM_139266.1, NM_139266.2, NM_007315.1, NM_007315.2, NM_007315.3, BC002704, BC002704.2, BC141921, NM_007315.4
UniProt ID P42224
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. The protein encoded by this gene can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. The protein plays an important role in immune responses to viral, fungal and mycobacterial pathogens. Mutations in this gene are associated with Immunodeficiency 31B, 31A, and 31C. provided by RefSeq, Jun 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Blockade of IDO-kynurenine-AhR metabolic circuitry abrogates IFN-γ-induced immunologic dormancy of tumor-repopulating cells
Liu, Liang, Yin et al
Nat Commun (2017) 8, 15207 DOI: 10.1038/ncomms15207
AI Summary: OriGene products—including pGFP-C-shLenti-shIDO1, pLenti-C-Myc-DDK-IDO1, pGFP-C-shLenti-shAHR, pCMV6-AHR, and pGFP-C-shLenti-shSTAT1—were used to manipulate the expression of key genes (IDO1, AHR, STAT1) to investigate their roles in IFN-γ-induced dormancy of tumor-repopulating cells.
Snippet: pGFP-C-shLenti-shIDO1, pLenti-C-Myc-DDK-IDO1, pGFP-C-shLenti-shAHR, pCMV6-AHR and pGFP-C-shLenti-shSTAT1 were purchased from Origene (MD, USA)
FigureFigureFigure
Showing 1-1 of 1 papers.
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