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STAT3 Human shRNA Plasmid Kit (Locus ID 6774)

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SKU
TL301348
STAT3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector, 5µg of each construct provided
  $1,013.00
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Specifications
Specifications
Product Data
Locus ID 6774
Synonyms ADMIO; ADMIO1; APRF; HIES
Vector pGFP-C-shLenti
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Lentiviral plasmids
Components STAT3 - Human, 4 unique 29mer shRNA constructs in lentiviral GFP vector(Gene ID = 6774). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-C-shLenti Vector, TR30021, included for free.
RefSeq NM_003150, NM_139276, NM_213662, NM_003150.1, NM_003150.2, NM_003150.3, NM_213662.1, NM_139276.1, NM_139276.2, BC014482, BC014482.1, BC000627, BC008044, BC029783, BC067119, BC107775, NM_001369512, NM_001369513, NM_001369514, NM_001369516, NM_001369517, NM_001369518, NM_001369519, NM_001369520, NM_003150.4, NM_139276.3, NM_213662.2
UniProt ID P40763
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. This gene also plays a role in regulating host response to viral and bacterial infections. Mutations in this gene are associated with infantile-onset multisystem autoimmune disease and hyper-immunoglobulin E syndrome. provided by RefSeq, Aug 2020
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
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file-alt Citations

PD-L1 is overexpressed on breast cancer stem cells through notch3/mTOR axis
Mansour, Al-Mazrou, Al-Mohanna et al
OncoImmunology (2020) 9 (1), 1729299 DOI: 10.1080/2162402X.2020.1729299
AI Summary: OriGene products, specifically the STAT3 (TL301348V) and c-Myc (TL311323V) shRNA lentiviral vectors, were used to effectively knock down these genes in breast cancer cells, enabling the study of their roles in PD-L1 regulation and cancer stem cell properties.
Snippet: STAT3 and c-Myc were also downregulated using specific ShRNA from OriGene (USA) in lentiviral vectors, (TL301348V, and TL311323V, respectively, using pGFP-C-ShLenti vector) as previously described9 (supplementary Table 2). Among the four plasmids (A, B, C, and D) provided by the company for each gene knockdown, plasmids (B) were the most effective in downregulating c-Myc and STAT3 in MDA-MB-231 cells (supplementary figure 11)
Interleukin-23 promotes the migration and invasion of gastric cancer cells by inducing epithelial-to-mesenchymal transition via the STAT3 pathway
Xu, Yang, Chen et al
Biochem. Biophys. Res. Commun. (2018)
AI Summary: OriGene products, specifically the shRNA-STAT3 lentiviral vectors, scrambled NC-shRNA lentiviral vectors, and shRNA lentiviral packaging kits, were used to knock down STAT3 expression in gastric cancer cells, enabling the study of STAT3's role in IL-23-induced migration, invasion, and epithelial-to-mesenchymal transition.
Snippet: 2.6. Plasmid constructs and transfection. The shRNA-STAT3 lentiviral vectors, scrambled NC-shRNA lentiviral vectors and shRNA lentiviral packaging kits were purchased from Origene (Beijing, China), and transfected following the manual instruction. 2.7
Microenvironmental interleukin-6 suppresses toll-like receptor signaling in human leukemia cells through miR-17/19A
Li, Shi, McCaw et al
Blood (2015)
Cited by 46
AI Summary: OriGene’s pGFP-C-shlenti vector was used to clone shRNA targeting STAT3, enabling the researchers to investigate the role of STAT3 in IL6-mediated suppression of TLR signaling in leukemia cells.
Snippet: shRNA-STAT3: An shRNA template was designed and cloned into the BamHI and BsmBI sites of pGFP-C-shlenti (ORIGENE, Rockville, USA). 19 Coding regions used to ... lenti (ORIGENE) with a H1 expression cassette to provide constitutive RNA polymerase ... Cite SaveSaving
Showing 1-3 of 3 papers.
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