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Sox2 Mouse shRNA Plasmid (Locus ID 20674)

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SKU
TG515613
Sox2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 20674
Synonyms lc; lcc; Sox; Sox-2; ys; ysb
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Sox2 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 20674). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC057574, NM_011443, NM_011443.1, NM_011443.2, NM_011443.3, NM_011443.4, BM938133
UniProt ID P48432
Summary This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in a similar gene in human have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (Sox2ot). provided by RefSeq, Sep 2015
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
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file-alt Citations

Efficient extravasation of tumor-repopulating cells depends on cell deformability
Chen, Zhou, Jia et al
Sci Rep (2016) 6, 19304 DOI: 10.1038/srep19304
Cited by 60
AI Summary: In this study, OriGene's Sox2 shRNAs (TG515613) were used to specifically silence Sox2 expression in tumor-repopulating cells, enabling the researchers to investigate the role of Sox2 in metastasis and cell deformability.
Snippet: … Cdc42 siRNAs was acquired from Invitrogen (catalogue number 66023) and the construct sequence is 5′-GGGCAAGAGGAUUAUGACATT-3′ for siRNA 1, and 5′-CCGCUAAGUUAUCCACAGATT-3′ for siRNA 2. Sox2 shRNAs were obtained from Origene (TG515613). …
FigureFigureFigure
Enhancer Analysis Unveils Genetic Interactions between TLX and SOX2 in Neural Stem Cells and In Vivo Reprogramming
Islam, Smith, Niu et al
Stem Cell Reports (2015) 5, 805-815 DOI: 10.1016/j.stemcr.2015.09.015
Cited by 40
AI Summary: OriGene’s Sox2- and Myt1-specific shRNAs, along with scrambled control shRNA, were used to knock down gene expression in mouse forebrains, enabling the authors to investigate the roles of these transcription factors in regulating TLX expression and neural stem cell function.
Snippet: Mouse P0 forebrains were transfected with Sox2- and Myt1-specific shRNAs or scrambled control (OriGene). All shRNAs were subcloned into the Superscript-GFP vector (shRNA sequences listed in Table S3)
Matrix softness regulates plasticity of tumour-repopulating cells via H3K9 demethylation and Sox2 expression
Tan, Tajik, Chen et al
Nat Commun (2014) 5, 4619 DOI: 10.1038/ncomms5619
Cited by 205
AI Summary: OriGene products, specifically Sox2 shRNAs (TG515613) and Sox2 cDNA (MG204615), were used to manipulate Sox2 expression and investigate its role in regulating self-renewal and plasticity of tumour-repopulating cells in this study.
Snippet: Sox2 shRNAs were obtained from Origene (TG515613). The construct sequence is 5′-GCACTACCAGAGCTAACTCAGATAGTACT-3′ for scrambled shRNA, 5′-GTATAACATGATGGAGACGGAGCTGAAGC-3′ for shRNA 1, 5′-AGACGCTCATGAAGAAGGATAAGTACACG-3′ for shRNA 2, 5′-AGCTACGCGCACATGAACGGCTGGAGCAA-3′ for shRNA 3, and 5′-AACATGATGGAGACGGAGCTGAAGCCGCC-3′ for shRNA 4. The ​Sox2 cDNA was obtained from Origene (MG204615)
Showing 1-3 of 3 papers.
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