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Vdr Mouse shRNA Plasmid (Locus ID 22337)

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SKU
TG513148
Vdr - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 22337
Synonyms Nr1i1
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Vdr - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 22337). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC006716, NM_009504, NM_009504.2, NM_009504.3, NM_009504.4
UniProt ID P48281
Summary Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells (By similarity). Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR (By similarity). The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes (By similarity). Plays a central role in calcium homeostasis (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

1,25-Dihydroxyvitamin D3 regulates furin-mediated FGF23 cleavage
Xie, Bastepe, Zhou et al
JCI Insight (2023) 8 (17) DOI: 10.1172/jci.insight.168957
Cited by 14
AI Summary: OriGene's shRNA lentivirus particles targeting Vdr (catalog TG513148) were used to transiently knock down Vdr expression in UMR106 cells, enabling the study of VDR's role in regulating furin-mediated FGF23 cleavage.
Snippet: shRNA transient KD was performed by shRNA lentivirus particles for Vdr that were purchased from Origene (catalog TG513148) and were transfected in UMR106 cells ( Save Cached
FigureFigureFigure
Vitamin D deficiency in rats causes cardiac dysfunction by inducing myocardial insulin resistance
Nizami, Katare, Prabhakar et al
Mol Nutr Food Res (2019)
AI Summary: OriGene’s VDR-targeting shRNA was used in this study to silence the vitamin D receptor in H9c2 cells, enabling the authors to investigate the role of vitamin D signaling in myocardial insulin resistance and cardiac dysfunction.
Snippet: Cells were treated with calcitriol (10 nM) for 2 hours, followed by addition of palmitate (400 μM;conjugated with BSA) and further incubation for 24 hours. VDR was silenced by transfecting the cells with VDR-targeting shRNA (Origene) Page 11. www.mnf-journal.com
Showing 1-2 of 2 papers.
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