E2f1 Mouse shRNA Plasmid (Locus ID 13555)

SKU
TG509487
E2f1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
In Stock*
Specifications
Specifications
Product Data
Locus ID 13555
Synonyms E2F-1; mKIAA4009; Tg(Wnt1-cre)2Sor
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components E2f1 - Mouse, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 13555). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC052160, NM_001291105, NM_007891, NM_007891.1, NM_007891.2, NM_007891.3, NM_007891.4, NM_007891.5, NM_001291105.1
UniProt ID Q61501
Summary Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTCCGCGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:11672531, PubMed:20176812). Positively regulates transcription of RRP1B (By similarity).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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