p53 (TP53) Human shRNA Plasmid Kit (Locus ID 7157)

SKU TG320558

TP53 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided

Product Data

• Locus ID: 7157
• Synonyms: BCC7; BMFS5; LFS1; P53; TRP53
• Vector: pGFP-V-RS
• E. coli Selection: Kan
• Format: Retroviral plasmids
• Components: TP53 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 7157). 5µg purified plasmid DNA per construct; 29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
• RefSeq: NM_000546, NM_001126112, NM_001126113, NM_001126114, NM_001126115, NM_001126116, NM_001126117, NM_001126118, NM_001276695, NM_001276696, NM_001276697, NM_001276698, NM_001276699, NM_001276760, NM_001276761, NM_000546.1, NM_000546.2, NM_000546.3, NM_000546.4, NM_000546.5, NM_001126116.1, NM_001126117.1, NM_001126115.1, NM_001126114.1, NM_001126114.2, NM_001126113.1, NM_001126113.2, NM_001126112.1, NM_001126112.2, NM_001276696.1, NM_001276695.1, NM_001126118.1, NM_001276760.1, NM_001276761.1, NM_001276698.1, NM_001276699.1, NM_001276697.1, BC003596, BC003596.1, NM_000546.6, NM_001276761.2, NM_001276699.2, NM_001276696.2, NM_001276698.2, NM_001276697.2, NM_001276695.2, NM_001276760.2
• UniProt ID: P04637
• Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]
• shRNA Design: These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
• Shipping: Ambient