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FGFR2 Human shRNA Plasmid Kit (Locus ID 2263)

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SKU
TG318702
FGFR2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 2263
Synonyms BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components FGFR2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 2263). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq BC039243, NM_000141, NM_001144913, NM_001144914, NM_001144915, NM_001144916, NM_001144917, NM_001144918, NM_001144919, NM_001320654, NM_001320658, NM_022969, NM_022970, NM_022971, NM_022972, NM_022973, NM_022974, NM_022975, NM_022976, NM_023028, NM_023029, NM_023030, NM_023031, NR_073009, NM_000141.1, NM_000141.2, NM_000141.3, NM_000141.4, NM_022970.1, NM_022970.2, NM_022970.3, NM_001144913.1, NM_001144914.1, NM_001144915.1, NM_001144916.1, NM_001144917.1, NM_001144918.1, NM_001144919.1, NM_023029.1, NM_023029.2, BC039243.1, NM_022971.1, BC037338, BC096749, NM_001144919.2, NM_001144917.2, NM_000141.5
UniProt ID P21802
Summary The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. provided by RefSeq, Jan 2009
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Neutralizing antibody to FGFR2 can act as a selective biomarker and potential therapeutic agent for gastric cancer with FGFR2 amplification
Kim, Lee, Rom et al
Am J Transl Res (2019) 11 (7), 4508-4515
AI Summary: OriGene’s shFGFR2 (TG318702) was used to generate FGFR2-knockdown gastric cancer cells, enabling the study to assess the specificity and effectiveness of the neutralizing antibody PRO-007 against FGFR2-amplified gastric cancer.
Snippet: immunoblotting. In addition, cells were transiently transfected by electroporation with short hairpin FGR2 (shFGFR2) TG318702 (Origene Technologies, Rockville, MD, USA) or scramble RNA. Immunoblot analysis. To evaluate
Showing 1-1 of 1 papers.
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