FGFR2 Mouse Monoclonal Antibody [Clone ID: OTI5C5]

SKU
TA503137
FGFR2 mouse monoclonal antibody, clone OTI5C5 (formerly 5C5)
  • TrueMAB

    Antibodies made against full-length proteins as antigens.

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$447.00
In Stock*
Specifications
Product Data
Clone Name OTI5C5
Application FC, IF, IHC, WB
Recommended Dilution WB 1:200 - 1:1000, IHC 1:150, IF 1:100, FLOW 1:100
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG2b
Clonality Monoclonal
Immunogen Full length human recombinant protein of human FGFR2(NP_000132) produced in HEK293T cell.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Gene Name fibroblast growth factor receptor 2
Database Link
Background The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq]
Synonyms BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; JWS; K-SAM; KGFR; TK14; TK25
Reference Data
Protein Families Druggable Genome, Protein Kinase, Secreted Protein, Transmembrane
Protein Pathways Endocytosis, MAPK signaling pathway, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton
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SKU Description Size Price
CF503137 Carrier-free (BSA/glycerol-free) FGFR2 mouse monoclonal antibody, clone OTI5C5 (formerly 5C5) 100 ug
$600.00
TA503137AM FGFR2 mouse monoclonal antibody,clone 5C5, Biotinylated 100 ul
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TA503137BM FGFR2 mouse monoclonal antibody,clone 5C5, HRP conjugated 100 ul
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TA503137S FGFR2 mouse monoclonal antibody, clone OTI5C5 (formerly 5C5) 30 ul
$200.00

Citations

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