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MDM2 Human shRNA Plasmid Kit (Locus ID 4193)

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SKU
TG311529
MDM2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 4193
Synonyms hdm2; HDMX; MGC5370; MGC71221
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components MDM2 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 4193). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001145336, NM_001145337, NM_001145339, NM_001145340, NM_001278462, NM_002392, NM_006878, NM_006879, NM_006880, NM_006881, NM_006882, NM_002392.1, NM_002392.2, NM_002392.3, NM_002392.4, NM_002392.5, NM_001145337.1, NM_001145337.2, NM_001145339.1, NM_001145339.2, NM_001145340.1, NM_001145340.2, NM_001278462.1, NM_001145336.1, NM_006878.2, NM_006879.2, NM_006881.2, NM_006882.2, BC006795, BC065505, BC107414, BC148522, BC152384, BC152390, BC153117, NM_001367990, NM_001145337.3, NM_001145340.3, NM_001278462.2
UniProt ID Q00987
Summary This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. provided by RefSeq, Jun 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Corosolic acid inhibits cancer progress through inactivating YAP in hepatocellular carcinoma
Jia, Xiong, Li et al
Oncol. Res. (2020)
AI Summary: OriGene products, including the YAP overexpressing lentivirus vector (Vector-YAP) and the short hairpin RNA targeting MDM2 (sh-MDM2), were used in this study to manipulate gene expression and investigate the molecular mechanisms by which corosolic acid inhibits cancer progression in hepatocellular carcinoma.
Snippet: … The short hairpin RNAs (shRNAs) used to downregulate human MDM2 (sh-MDM2) and;- control vector (Vector-NC), as well as the overexpressing lentivirus vector used to upregulate YAP (Vector-YAP) were all purchased from OriGene (Rockville, MD, USA). The short hairpin RNAs (shRNAs) used to downregulate human MDM2 (sh-MDM2) and
FATS is an E2-independent ubiquitin ligase that stabilizes p53 and promotes its activation in response to DNA damage
Yan, Qiu, Ma et al
Oncogene (2013)
Cited by 25
AI Summary: OriGene products contributed to this study by providing human FATS-shRNA (TG315108) and Mdm2-shRNA (TG311529), which were used to knock down FATS and Mdm2 expression and investigate their roles in p53 stabilization and activation.
Snippet: described. 24, 38 The Renilla luciferase reporter pRL-TK was obtained from Promega (Fitchburg, WI, USA). Human FATS-shRNA (TG315108) and Mdm2-shRNA (TG311529) were purchased from Origene (Rockville, MD, USA). GST ... Cite SaveSaving
Showing 1-2 of 2 papers.
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