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CDC42 Human shRNA Plasmid Kit (Locus ID 998)

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SKU
TG305497
CDC42 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 998
Synonyms CDC42Hs; G25K; TKS
Vector pGFP-V-RS
E. coli Selection Kanamycin
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components CDC42 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 998). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001039802, NM_001791, NM_044472, NM_001791.1, NM_001791.2, NM_001791.3, NM_044472.1, NM_044472.2, NM_001039802.1, BC018266, BC018266.1, BC002711, BC003682, BC018622, BM684474, NM_001791.4, NM_044472.3, NM_001039802.2
UniProt ID P60953
Summary The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. Pseudogenes of this gene have been identified on chromosomes 3, 4, 5, 7, 8 and 20. provided by RefSeq, Apr 2013
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Mir20a/106a-WTX axis regulates RhoGDIa/CDC42 signaling and colon cancer progression
Zhu, Xu, Li et al
Nat Commun (2019) 10 (1), 112 DOI: 10.1038/s41467-018-07998-x
AI Summary: OriGene products contributed shRNAs targeting WTX, CDC42, and RhoGDIa, which were used to generate knockdown cell lines for functional studies in this paper.
Snippet: … Then, the pEGFP-N1-WTX vector was transfected into SW620 and HT29 cells to establish the WTX overexpression subclone cell lines. The shRNA of WTX, CDC42, and RhoGDIa were purchased from Origene Company (Beijin, China) and transfected into SW480 and HCT116 cells to establish the WTX knockdown subclone cell lines
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Showing 1-1 of 1 papers.
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