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SPHK1 Human shRNA Plasmid Kit (Locus ID 8877)

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TG301413
SPHK1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector, 5µg of each construct provided
  $883.00
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Specifications
Specifications
Product Data
Locus ID 8877
Synonyms SPHK
Vector pGFP-V-RS
E. coli Selection Kanamycin
Format Retroviral plasmids
Components SPHK1 - Human, 4 unique 29mer shRNA constructs in retroviral GFP vector(Gene ID = 8877). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pGFP-V-RS Vector, TR30013, included for free.
RefSeq NM_001142601, NM_001142602, NM_021972, NM_182965, NM_001355139, NM_021972.1, NM_021972.2, NM_021972.3, NM_182965.1, NM_182965.2, NM_001142602.1, NM_001142601.1, BC009419, BC009419.1, BC030553, BC008040, BC004112, BC014439, NM_021972.4
UniProt ID Q9NYA1
Summary The protein encoded by this gene catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P), a lipid mediator with both intra- and extracellular functions. Intracellularly, S1P regulates proliferation and survival, and extracellularly, it is a ligand for cell surface G protein-coupled receptors. This protein, and its product S1P, play a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory, antiapoptotic, and immune processes. Phosphorylation of this protein alters its catalytic activity and promotes its translocation to the plasma membrane. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Sep 2017
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
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