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Usp9x Mouse shRNA Plasmid (Locus ID 22284)

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SKU
TF510959
Usp9x - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 22284
Synonyms 5730589N07Rik; AA407302; AA407699; AL022658; AL022749; Dffrx; FAF-X; Fafl
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Usp9x - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 22284). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_009481, NM_009481.1, NM_009481.2
UniProt ID P70398
Summary Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Specifically hydrolyzes 'Lys-48'-, 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Essential component of TGF-beta/BMP signaling cascade. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres (By similarity). Involved in axonal growth and neuronal cell migration (By similarity) (PubMed:24607389). Regulates cellular clock function by enhancing the protein stability and transcriptional activity of the core circadian protein ARNTL/BMAL1 via its deubiquitinating activity (PubMed:29626158).UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance
Yoon, Parnell, Penzes
Cell Rep (2020) 31 (8), 107685 DOI: 10.1016/j.celrep.2020.107685
Cited by 19
AI Summary: In this study, OriGene’s Usp9X (mouse, Cat# MR207796) and Ank3/Ankyrin-G (mouse, Cat# MR215565) cDNA clones were used to investigate how TGF-β-induced phosphorylation of Usp9X stabilizes Ankyrin-G, thereby regulating dendritic spine development and maintenance.
FigureFigureFigure
TGFβ-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Maintenance
Yoon, Parnell, Penzes
SSRN Journal (2020)
Cited by 1
Snippet: GeneCopoeia Cat#EX-Mm24322- M12 Page 22. pRFP-C-RS Control Origene Cat#TR30015 pRFP-C-RS shUsp9X Origene Cat#TF510959 pGFP-C-RS shAnkG Smith et al., 2014 http://www.cell.com/n euron/abstract/S0896- 6273(14)00908-8 pmCherry-C1
TGF-β-Induced Phosphorylation of Usp9X Stabilizes Ankyrin-G and Regulates Dendritic Spine Development and Maintenance
Yoon, Parnell, Penzes
Cell Rep (2020) 31 (8), 107685 DOI: 10.1016/j.celrep.2020.107685
Cited by 19
AI Summary: OriGene’s pRFP-C-RS Control (Cat# TR30015) and pRFP-C-RS shUsp9X (Cat# TF510959) shRNA constructs were used in this study to manipulate and identify Usp9X expression in transfected cells, enabling the investigation of its role in dendritic spine development and maintenance.
Snippet: …The N-terminal fragment of 3XHA-AnkG (amino acid;pEZ-3XHA-AnkG GeneCopoeia Cat# EX-Mm25668-M06 pEZ-3XFlag-Usp9X GeneCopoeia Cat#EX-Mm24322-M12 pRFP-C-RS Control Origene Cat#TR30015 pRFP-C-RS shUsp9X Origene Cat#TF510959
Showing 1-3 of 3 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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