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Hmox1 Mouse shRNA Plasmid (Locus ID 15368)

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SKU
TF500966
Hmox1 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 15368
Synonyms D8Wsu38e; Hemox; Hmox; HO-1; HO1; Hsp32
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Hmox1 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 15368). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC010757, NM_010442, NM_010442.1, NM_010442.2
UniProt ID P14901
Summary Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed. Exhibits cytoprotective effects since excess of free heme sensitizes cells to undergo apoptosis.UniProtKB/Swiss-Prot Function
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

Heme Oxygenase-1 Differentially Controls Pigmentation in Physiological and Pathological Melanogenesis
Seretny, Jamróg, Stępniewski et al
Pigment Cell Melanoma Res (2026) 39 (4), e70105 DOI: 10.1111/pcmr.70105
AI Summary: OriGene's Hmox1 mouse shRNA constructs (TF500966) were used to achieve HO-1 knockdown in B16-F10 and Melan-A cells, enabling the study of HO-1's role in regulating pigmentation in melanoma and normal melanocytes.
Snippet: ="pcmr70105-bib-0038" ref-type="bibr">2022). HO‐1 knockdown in B16‐F10 and Melan‐A cells was achieved by RVs transduction with Hmox1 mouse shRNA constructs (OriGENE, TF500966). For RVs production, Phoenix‐Eco cells were transfected with four different shHO‐1 plasmids and one scrambled control (Table 
FigureFigureFigure
Showing 1-1 of 1 papers.
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