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Trp53 Mouse shRNA Plasmid (Locus ID 22059)

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SKU
TF500002
Trp53 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 22059
Synonyms bbl; bfy; bhy; p4; p5; p44; p53; Tp53
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components Trp53 - Mouse, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 22059). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq BC005448, NM_001127233, NM_011640, NM_011640.1, NM_011640.2, NM_011640.3, NM_001127233.1
UniProt ID P02340
Summary This gene encodes tumor protein p53, which responds to diverse cellular stresses to regulate target genes that induce cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 is a DNA-binding protein containing transcription activation, DNA-binding, and oligomerization domains. It is postulated to bind to a p53-binding site and activate expression of downstream genes that inhibit growth and/or invasion, and thus function as a tumor suppressor. Mice deficient for this gene are developmentally normal but are susceptible to spontaneous tumors. Evidence to date shows that this gene contains one promoter, in contrast to alternative promoters of the human gene, and transcribes a few of splice variants which encode different isoforms, although the biological validity or the full-length nature of some variants has not been determined. provided by RefSeq, Jul 2008
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
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Documents
Resources

file-alt Citations

Gene expression profiles resulting from stable loss of p53 mirrors its role in tissue differentiation
Couture, Lombardi, Davis et al
PLoS One (2013) 8 (11), e82494 DOI: 10.1371/journal.pone.0082494
Cited by 6
AI Summary: OriGene products contributed to this study by providing the p53 shRNA (OriGene, Cat# TL315966) used for stable knockdown of p53 in C2C12 cells, enabling the authors to assess gene expression changes resulting from long-term p53 loss.
FigureFigureFigure
Showing 1-1 of 1 papers.
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