LGR5 Human shRNA Plasmid Kit (Locus ID 8549)
SKU
TF311747
LGR5 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
$883.00
In Stock*
Specifications
| Product Data | |
| Locus ID | 8549 |
|---|---|
| Synonyms | FEX; GPR49; GPR67; GRP49; HG38 |
| Vector | pRFP-C-RS |
| E. coli Selection | Chloramphenicol (34 ug/ml) |
| Mammalian Cell Selection | Puromycin |
| Format | Retroviral plasmids |
| Components | LGR5 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 8549). 5µg purified plasmid DNA per construct29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free. |
| RefSeq | NM_001277226, NM_001277227, NM_003667, NR_110596, NM_003667.1, NM_003667.2, NM_003667.3, NM_001277227.1, NM_001277226.1, BC096324, BC096325, BC096326, BC099650, NM_001277226.2, NM_001277227.2, NM_003667.4 |
| UniProt ID | O75473 |
| Summary | The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. provided by RefSeq, Sep 2015 |
| shRNA Design | These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service. |
| Storage | Store at -20°C |
| Shipping | Ambient |
Reviews
Documents
Resources
Citations
FOXO1 reduces tumorsphere formation capacity and has crosstalk with LGR5 signaling in gastric cancer cells
Choi, Park, Ko et al
Biochem. Biophys. Res. Commun. (2017) 493 (3), 1349-1355 DOI: 10.1016/j.bbrc.2017.09.163
Choi, Park, Ko et al
Biochem. Biophys. Res. Commun. (2017) 493 (3), 1349-1355 DOI: 10.1016/j.bbrc.2017.09.163
AI Summary: OriGene’s pRFP-C-RS vectors containing either control non-targeting shRNA or LGR5 shRNA were used in this study to manipulate LGR5 expression and investigate its interaction with FOXO1 in gastric cancer cell stemness.
Snippet: … The pRFP-C-RS vectors containing either control non-targeting shRNA or LGR5 shRNA (5′-ATCAGTTACCTAATCTCCAAGT GCTAGAT-3′) were purchased from OriGene (Rockville, MD, USA). ...;... … The pRFP-C-RS vectors containing either control non-targeting shRNA or LGR5 shRNA (5′-ATCAGTTACCTAATCTCCAAGT GCTAGAT-3′) were purchased from OriGene (Rockville, MD, USA).
LGR5 is associated with tumor aggressiveness in papillary thyroid cancer
Michelotti, Jiang, Sosa et al
Oncotarget (2015) 6 (33), 34549-60 DOI: 10.18632/oncotarget.5330
Michelotti, Jiang, Sosa et al
Oncotarget (2015) 6 (33), 34549-60 DOI: 10.18632/oncotarget.5330
Cited by 31
AI Summary: OriGene products, specifically LGR5 (RC221445) and RSPO2 (RC210125) expression plasmids, were used to manipulate gene expression in cell lines to investigate the role of LGR5 and its ligand in papillary thyroid cancer aggressiveness.
Showing 1-2 of 2 papers.
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