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USP7 Human shRNA Plasmid Kit (Locus ID 7874)

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SKU
TF308454
USP7 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
In Stock*

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Specifications
Specifications
Product Data
Locus ID 7874
Synonyms HAFOUS; HAUSP; TEF1
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components USP7 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 7874). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001286457, NM_001286458, NM_003470, NM_001321858, NR_135826, NM_003470.1, NM_001286458.1, NM_001286457.1, BC166690, BM661563, NM_001286458.2, NM_003470.3
UniProt ID Q93009
Summary The protein encoded by this gene belongs to the peptidase C19 family, which includes ubiquitinyl hydrolases. This protein deubiquitinates target proteins such as p53 (a tumor suppressor protein) and WASH (essential for endosomal protein recycling), and regulates their activities by counteracting the opposing ubiquitin ligase activity of proteins such as HDM2 and TRIM27, involved in the respective process. Mutations in this gene have been implicated in a neurodevelopmental disorder. provided by RefSeq, Mar 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway
Zhang, Periz, Lu et al
Proc Natl Acad Sci U S A (2020)
Cited by 57
AI Summary: OriGene products, specifically the USP7 shRNA plasmid (pRFP-C-RS, catalog no. TF308454) and the scrambled control plasmid (catalog no. TR30015), were used in this study to manipulate USP7 expression and investigate its role in regulating protein quality control in ALS models.
Snippet: The plasmids expressing USP7 shRNAs with a red fluorescent protein (RFP) marker (pRFP-C-RS, catalog no. TF308454) and the scrambled control (catalog no. TR30015) were from OriGene Technologies Inc. The SMAD2 shRNA sequence (5′-CATGATCCAGTATCACAGTAT-3′) was cloned into an L4R1-H1-promoter plasmid and used with a scrambled shRNA control as described previously (18)
Showing 1-1 of 1 papers.
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