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BMP4 Human shRNA Plasmid Kit (Locus ID 652)

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SKU
TF306390
BMP4 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector, 5µg of each construct provided
  $883.00
2 Weeks*

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Specifications
Specifications
Product Data
Locus ID 652
Synonyms BMP2B; BMP2B1; MCOPS6; OFC11; ZYME
Vector pRFP-C-RS
E. coli Selection Chloramphenicol (34 ug/ml)
Mammalian Cell Selection Puromycin
Format Retroviral plasmids
Components BMP4 - Human, 4 unique 29mer shRNA constructs in retroviral RFP vector(Gene ID = 652). 5µg purified plasmid DNA per construct
29-mer scrambled shRNA cassette in pRFP-C-RS Vector, TR30015, included for free.
RefSeq NM_001202, NM_130850, NM_130851, NM_001347912, NM_001347913, NM_001347914, NM_001347915, NM_001347916, NM_001347917, NM_001202.1, NM_001202.2, NM_001202.3, NM_001202.4, NM_001202.5, NM_130850.1, NM_130850.2, NM_130850.3, NM_130850.4, NM_130851.1, NM_130851.2, NM_130851.3, BC020546, BC020546.2
UniProt ID P12644
Summary This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. This protein regulates heart development and adipogenesis. Mutations in this gene are associated with orofacial cleft and microphthalmia in human patients. The encoded protein may also be involved in the pathology of multiple cardiovascular diseases and human cancers. provided by RefSeq, Jul 2016
shRNA Design These shRNA constructs were designed against multiple splice variants at this gene locus. To be certain that your variant of interest is targeted, please contact techsupport@origene.com. If you need a special design or shRNA sequence, please utilize our custom shRNA service.
Storage Store at -20°C
Shipping Ambient
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Documents
Resources

file-alt Citations

BMP4 Upregulation Is Associated with Acquired Drug Resistance and Fatty Acid Metabolism in EGFR-Mutant Non-Small-Cell Lung Cancer Cells
Bach, Luu, Kim et al
Mol Ther Nucleic Acids (2018) 12, 817-828 DOI: 10.1016/j.omtn.2018.07.016
AI Summary: OriGene products, specifically lentiviral particles for gene delivery, were used to introduce target genes into NSCLC cells to establish stable cell lines for investigating the role of BMP4 in EGFR-TKI resistance.
Snippet: M ANUSCRIPT ACCEPTED ACCEPTED MANUSCRIPT 11 Origene (Rockville MD, USA) and introduced into the indicated cells by viral infection. Stable cell lines were established following greater than 2 weeks of antibiotic selection according to the manufacturer's
Showing 1-1 of 1 papers.
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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