VEGFA (NM_001025366) Human Recombinant Protein

CAT#: TP780002

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Purified recombinant protein of Human vascular endothelial growth factor A (VEGFA), transcript variant 1, expressed in Pichia Pastoris, 200ug.


 Product Datasheet for 'TP780002'

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USD 822.00


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    • 200 ug


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Product Data
Description Purified recombinant protein of Human vascular endothelial growth factor A (VEGFA), transcript variant 1, expressed in Pichia Pastoris, 200ug.
Species Human
Expression Host Pichia
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC223789, encoding the region (Ala27-Arg232) of VEGFA
Tag Tag Free
Predicted MW 23.9 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing 1xPBS, pH7.4
Reference Data
RefSeq NP_001020537
Locus ID 7422
Refseq Size 3665
Cytogenetics 6p21.1
Refseq ORF 1236
Synonyms MVCD1; VEGF; VPF
Summary This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. [provided by RefSeq, Nov 2015]
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Bladder cancer, Cytokine-cytokine receptor interaction, Focal adhesion, mTOR signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, VEGF signaling pathway

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