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VEGFA (NM_001025366) Human Recombinant Protein

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SKU
TP780002
Purified recombinant protein of Human vascular endothelial growth factor A (VEGFA), transcript variant 1, expressed in Pichia Pastoris, 200ug.
Size:
200 ug
  $1,040.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host Pichia
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC223789, encoding the region (Ala27-Arg232) of VEGFA
Tag Tag Free
Predicted MW 23.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a sterile solution containing PBS, pH 7.4
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -20°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Ambient
Reference Data
RefSeq NP_001020537
Locus ID 7422
UniProt ID P15692
Cytogenetics 6p21.1
RefSeq Size 3665
RefSeq ORF 1236
Synonyms MVCD1; VEGF; VPF
Summary This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site. The levels of VEGF are increased during infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), thus promoting inflammation by facilitating recruitment of inflammatory cells, and by increasing the level of angiopoietin II (Ang II), one of two products of the SARS-CoV-2 binding target, angiotensin-converting enzyme 2 (ACE2). In turn, Ang II facilitates the elevation of VEGF, thus forming a vicious cycle in the release of inflammatory cytokines. provided by RefSeq, Jun 2020
Protein Categories Cytokines, Endocrine and metabolic diseases, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system Diseases, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein
Protein Pathways Bladder cancer, Cytokine-cytokine receptor interaction, Focal adhesion, mTOR signaling pathway, Pancreatic cancer, Pathways in cancer, Renal cell carcinoma, VEGF signaling pathway
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Other "VEGFA" proteins (9)
SKU Description Size Price
LC422419 Lyophilized VEGFA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC422435 Lyophilized VEGFA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC422439 Lyophilized VEGFA HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY422419 Transient overexpression lysate of vascular endothelial growth factor A (VEGFA), transcript variant 7 (as WB positive control) 100 ug
$436.00
LY422435 Transient overexpression lysate of vascular endothelial growth factor A (VEGFA), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY422439 Transient overexpression lysate of vascular endothelial growth factor A (VEGFA), transcript variant 6 (as WB positive control) 100 ug
$436.00
TP723804 Purified recombinant protein of Human vascular endothelial growth factor A (VEGFA), transcript variant 6 10 ug
$460.00
TP723809 Purified recombinant protein of Human vascular endothelial growth factor A (VEGFA), transcript variant 2 10 ug
$460.00
TP780001 Recombinant protein of human Vascular endothelial growth factor A (VEGF) produced in Pichia Pastoris. 50 ug
$540.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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