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MET (NM_000245) Human Recombinant Protein

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SKU
TP762492
Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, 1100Asn-End, with N-terminal His tag, expressed in E.coli, 50ug
Size:
50 ug
  $240.00
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding the region (1100Asn-End) of MET
Tag N-His
Predicted MW 35.4kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, pH 8.0, 8 M urea
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C after receiving vials.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000236
Locus ID 4233
UniProt ID P08581 A0A024R759
Cytogenetics 7q31.2
RefSeq Size 6641
RefSeq ORF 4170
Synonyms AUTS9; c-Met; DFNB97; HGFR; RCCP2
Summary This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. provided by RefSeq, May 2016
Protein Categories ADC Targets, Cancer: Bladder, Cancer: Gastrointestinal, Cancer: Lung, Cancer: Sarcoma, CAR-T Targets, Enzyme: Kinases, Growth Factors, Intracellular Proteins, Membrane Proteins, Nervous system Diseases, Secreated Proteins
Protein Families Druggable Genome, Protein Kinase, Transmembrane
Protein Pathways Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma
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Other "MET" proteins (9)
SKU Description Size Price
PH317003 MET MS Standard C13 and N15-labeled recombinant protein (NP_000236) 10 ug
$3,360.00
LC400094 Lyophilized MET HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC426803 Lyophilized MET HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400094 Transient overexpression lysate of met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2 (as WB positive control) 100 ug
$665.00
LY426803 Transient overexpression lysate of met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 1 (as WB positive control) 100 ug
$665.00
TP317003 Recombinant protein of human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, 20 µg 20 ug
$737.00
TP700130 Purified recombinant protein of human met proto-oncogene (hepatocyte growth factor receptor)(MET), transcript variant 2, with C-terminal DDK/His tag, expressed in human cells, 20 µg 20 ug
$900.00
TP750192 Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, Thr678-Ile743, tag free, expressed in E.coli, 50ug 50 ug
$380.00
TP762409 Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, Phe146-Thr230-GGGGS-Ile850-Leu920, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$260.00

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