MET (NM_000245) Human Mass Spec Standard
$3,360.00
3 Weeks*
Specifications
| Product Data | |
| Tag | C-Myc/DDK |
|---|---|
| Species | Human |
| Expression Host | HEK293 |
| Expression cDNA Clone or AA Sequence | RC217003 |
| Predicted MW | 155.54 kDa |
| Protein Sequence | |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Labeling Method | Labeled with U- 13C6, 15N4-L-Arginine and U- 13C6, 15N2-L-Lysine |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3 |
| Storage | Store at -80°C. Avoid repeated freeze-thaw cycles. |
| Stability | Stable for 3 months from receipt of products under proper storage and handling conditions. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_000236 |
| RefSeq Size | 6641 |
| RefSeq ORF | 4170 |
| Synonyms | AUTS9; c-Met; DFNB97; HGFR; RCCP2 |
| Locus ID | 4233 |
| UniProt ID | P08581 |
| Cytogenetics | 7q31.2 |
| Summary | This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. provided by RefSeq, May 2016 |
| Protein Families | Druggable Genome, Protein Kinase, Transmembrane |
| Protein Pathways | Adherens junction, Axon guidance, Colorectal cancer, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection, Focal adhesion, Melanoma, Pathways in cancer, Renal cell carcinoma |
Reviews
Documents
| FAQs |
| SDS |
Resources
| Recombinant Protein Resources |
Other "MET" proteins (9)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| LC400094 | Lyophilized MET HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LC426803 | Lyophilized MET HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY400094 | Transient overexpression lysate of met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2 (as WB positive control) | 100 ug |
$665.00
|
|
| LY426803 | Transient overexpression lysate of met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 1 (as WB positive control) | 100 ug |
$665.00
|
|
| TP317003 | Recombinant protein of human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, 20 µg | 20 ug |
$737.00
|
|
| TP700130 | Purified recombinant protein of human met proto-oncogene (hepatocyte growth factor receptor)(MET), transcript variant 2, with C-terminal DDK/His tag, expressed in human cells, 20 µg | 20 ug |
$900.00
|
|
| TP750192 | Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, Thr678-Ile743, tag free, expressed in E.coli, 50ug | 50 ug |
$380.00
|
|
| TP762409 | Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, Phe146-Thr230-GGGGS-Ile850-Leu920, with N-terminal His tag, expressed in E.coli, 50ug | 50 ug |
$260.00
|
|
| TP762492 | Purified recombinant protein of Human met proto-oncogene (hepatocyte growth factor receptor) (MET), transcript variant 2, 1100Asn-End, with N-terminal His tag, expressed in E.coli, 50ug | 50 ug |
$240.00
|
|
Citations
MET receptor sequence variants R970C and T992I lack transforming capacity
Tyner, Fletcher, Wang et al
Cancer Res (2010) 70 (15), 6233-7 DOI: 10.1158/0008-5472.CAN-10-0429
Tyner, Fletcher, Wang et al
Cancer Res (2010) 70 (15), 6233-7 DOI: 10.1158/0008-5472.CAN-10-0429
AI Summary: OriGene products, specifically the pCMV6-MET expression plasmids, were used to express wild-type and variant MET receptors in cell lines, enabling the authors to assess and compare the phosphorylation and transforming abilities of the R970C and T992I MET variants.
Showing 1-1 of 1 papers.
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