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E2F3 (NM_001949) Human Recombinant Protein

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SKU
TP760363
Purified recombinant protein of Human E2F transcription factor 3 (E2F3), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length E2F3
Tag N-His
Predicted MW 49 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Bioactivity WB standard (PMID: 26639898)
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_001940
Locus ID 1871
UniProt ID O00716
Cytogenetics 6p22.3
RefSeq Size 4744
RefSeq ORF 1395
Synonyms E2F-3
Summary This gene encodes a member of a small family of transcription factors that function through binding of DP interaction partner proteins. The encoded protein recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle. Altered copy number and activity of this gene have been observed in a number of human cancers. There are pseudogenes for this gene on chromosomes 2 and 17. Alternative splicing results in multiple transcript variants. provided by RefSeq, Mar 2013
Protein Categories Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer
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Documents
Resources
Other "E2F3" proteins (2)
SKU Description Size Price
LC400716 Lyophilized E2F3 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400716 Transient overexpression lysate of E2F transcription factor 3 (E2F3) (as WB positive control) 100 ug
$665.00

file-alt Citations

Recruitment of Pontin/Reptin by E2f1 amplifies E2f transcriptional response during cancer progression
Tarangelo, Lo, Teng et al
Nat Commun (2015) 6, 10028 DOI: 10.1038/ncomms10028
Cited by 67
AI Summary: In this paper, OriGene products—specifically the pCMV6-E2f1 expression plasmid and E2f1 shRNA lentiviral particles—were used to modulate E2f1 levels in cells, enabling the authors to investigate how E2f1 recruitment of the Pontin/Reptin complex amplifies E2f transcriptional responses during cancer progression.
Snippet: Cite SaveSaving
Showing 1-1 of 1 papers.
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