E2F3 Rabbit Polyclonal Antibody

SKU
TA349084
Rabbit Polyclonal Anti-E2F3 Antibody
  $640.00
5 Days*
Bulk/Customize
Specifications
Specifications
Product Data
Application IF, IHC, WB
Recommended Dilution WB: 1 - 2 ug/mL, IHC: 5 ug/mL, IF: 20 ug/mL
Reactivity Human, Mouse
Antibody Host Rabbit
Isotype IgG
Clonality Polyclonal
Immunogen E2F3 antibody was raised against a 15 amino acid peptide near the center of human E2F3.
Buffer PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification E2F3 antibody is affinity chromatography purified via peptide column.
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size Predicted: 51 kDa; Observed: 56 kDa
Gene Name E2F transcription factor 3
Database Link
Background The E2F transcription factor 3 (E2F3) is a member of a small family of transcription factors that function through binding of DP interaction partner proteins. E2F3 recognizes a specific sequence motif in DNA and interacts directly with the retinoblastoma protein (pRB) to regulate the expression of genes involved in the cell cycle (1). Like the related E2F1 and E2F2, E2F3 is essential for cellular proliferation and progression through the cell cycle (2). Altered copy number and activity of this gene have been observed in a number of human cancers (3).
Synonyms E2F-3
Reference Data
Protein Categories Intracellular Proteins, Transciption Factors
Protein Families Druggable Genome, Transcription Factors
Protein Pathways Bladder cancer, Cell cycle, Chronic myeloid leukemia, Glioma, Melanoma, Non-small cell lung cancer, Pancreatic cancer, Pathways in cancer, Prostate cancer, Small cell lung cancer
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