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SDHB (NM_003000) Human Recombinant Protein

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SKU
TP760076
Recombinant protein of human succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein, full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length SDHB
Tag N-His
Predicted MW 31.6 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 1% sarkosyl, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_002991
Locus ID 6390
UniProt ID P21912
Cytogenetics 1p36.13
RefSeq Size 1161
RefSeq ORF 840
Synonyms CWS2; IP; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP
Summary Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. provided by RefSeq, Jul 2008
Protein Categories Cancer: Endocrine, Cancer: Gastrointestinal, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease
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Other "SDHB" proteins (2)
SKU Description Size Price
LC401052 Lyophilized SDHB HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401052 Transient overexpression lysate of succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB), nuclear gene encoding mitochondrial protein (as WB positive control) 100 ug
$436.00

file-alt Citations

APOBEC3A cytidine deaminase induces RNA editing in monocytes and macrophages
Sharma, Patnaik, Thomas Taggart et al
Nat Commun (2015) 6, 6881 DOI: 10.1038/ncomms7881
Cited by 283
AI Summary: OriGene contributed to this study by providing plasmid constructs for human APOBEC3A (RC220995), APOBEC3G (SC122916), CDA (SC119015), and SDHB (SC319204), which were used to express and analyze the roles of these proteins in RNA editing experiments.
Snippet: Gene expression constructs and site-directed mutagenesis Sequence-verified plasmid constructs in pCMV6 vector for cytomegalovirus (CMV) promoter-driven expression of human APOBEC3A, APOBEC3G, CDA and SDHB cDNAs, with sequences matching NCBI RefSeq sequences NM_145699.2, NM_021822.1, NM_001785.1 and NM_003000.2, respectively, for the generation of C-terminal Myc-DDK-tagged APOBEC3A and untagged APOBEC3G, CDA and SDHB proteins were obtained from OriGene (Rockville, MD;product numbers RC220995, SC122916, SC119015 and SC319204, respectively)
Showing 1-1 of 1 papers.
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