SDHB Mouse Monoclonal Antibody [Clone ID: OTI3F5]

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TA808102
SDHB mouse monoclonal antibody, clone OTI3F5 (formerly 3F5)
  $447.00
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Specifications
Specifications
Product Data
Clone Name OTI3F5
Application IHC, Simple Western, WB
Recommended Dilution WB 1:2000, IHC 1:150 ; Simple Western 1:20-1:50
Reactivity Human, Mouse, Rat
Antibody Host Mouse
Isotype IgG1
Clonality Monoclonal
Immunogen Full length human recombinant protein of human SDHB(NP_002991) produced in E.coli.
Buffer PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide
Concentration 1 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation Unconjugated
Storage Store at -20°C as received.
Stability Stable for 12 months from date of receipt.
Shipping Blue Ice
Predicted Protein Size 28.8 kDa
Gene Name succinate dehydrogenase complex iron sulfur subunit B
Database Link
Background Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis. provided by RefSeq, Jul 2008
Synonyms CWS2; IP; MC2DN4; PGL4; SDH; SDH1; SDH2; SDHIP
Reference Data
Protein Categories Cancer: Endocrine, Cancer: Gastrointestinal, Intracellular Proteins
Protein Families Druggable Genome
Protein Pathways Alzheimer's disease, Citrate cycle (TCA cycle), Huntington's disease, Metabolic pathways, Oxidative phosphorylation, Parkinson's disease
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Other "OTI3F5" antibodies (4)
SKU Description Size Price
CF808102 Carrier-free (BSA/glycerol-free) SDHB mouse monoclonal antibody, clone OTI3F5 (formerly 3F5) 100 ug
$620.00
TA808102AM SDHB mouse monoclonal antibody, clone OTI3F5 (formerly 3F5), Biotinylated 100 ul
$509.00
TA808102BM SDHB mouse monoclonal antibody, clone OTI3F5 (formerly 3F5), HRP conjugated 100 ul
$509.00
TA808102S SDHB mouse monoclonal antibody, clone OTI3F5 (formerly 3F5) 30 ul
$200.00

file-alt Citations

NDUFAB1 confers cardio-protection by enhancing mitochondrial bioenergetics through coordination of respiratory complex and supercomplex assembly
Hou, Zhang, Jian et al
Cell Res. (2019) 29 (9), 754-766 DOI: 10.1038/s41422-019-0208-x
AI Summary: OriGene products, specifically antibodies against NDUFAB1, SDHB, and SDHD, were used in this study to detect and analyze mitochondrial respiratory complex proteins, enabling the authors to assess the effects of NDUFAB1 on mitochondrial bioenergetics and cardio-protection.
Snippet: …The antibodies for NDUFAB1, SDHB, and SDHD were from Origene, those for NDUFB8, NDUFS4, SDHA, UQCRC1, UQCRB, ATPB, ATP5A, AcK103, and lipoic acid from Abcam, and those for NDUFS1, NDUFS6, NDUFS7, UQCRFS1, COXIV, ISCU, and NFS1 from ProteinTech
WB
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