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BMI1 (NM_005180) Human Recombinant Protein

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SKU
TP760041
Recombinant protein of human BMI1 polycomb ring finger oncogene (BMI1), full length, with N-terminal HIS tag, expressed in E.Coli, 50ug
Size:
50 ug
  $270.00
In Stock*
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Frequently Bought Together (1)

TA325069 BMI1 Antibody
400 ul
$645.00

Other products for "BMI1 or NM_005180"

Specifications
Specifications
Product Data
Species Human
Expression Host E. coli
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence encoding human full-length BMI1
Tag N-His
Predicted MW 36.9 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris-HCl, pH 8.0, 150 mM NaCl, 100 mM arginine, 10% glycerol
Bioactivity In vitro kinase assay substrate (PMID: 28270146)
Binding assay (competitor) (PMID: 29402932)
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_005171
Locus ID 648
UniProt ID P35226
Cytogenetics 10p12.2
RefSeq Size 3435
RefSeq ORF 978
Synonyms flvi-2/bmi-1; FLVI2/BMI1; PCGF4; RNF51
Summary This gene encodes a ring finger protein that is major component of the polycomb group complex 1 (PRC1). This complex functions through chromatin remodeling as an essential epigenetic repressor of multiple regulatory genes involved in embryonic development and self-renewal in somatic stem cells. This protein also plays a central role in DNA damage repair. This gene is an oncogene and aberrant expression is associated with numerous cancers and is associated with resistance to certain chemotherapies. A pseudogene of this gene is found on chromosome X. Read-through transcription also exists between this gene and the upstream COMM domain containing 3 (COMMD3) gene. provided by RefSeq, Sep 2015
Protein Categories Intracellular Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transcription Factors
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Other "BMI1" proteins (2)
SKU Description Size Price
LC401584 Lyophilized BMI1 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY401584 Transient overexpression lysate of BMI1 polycomb ring finger oncogene (BMI1) (as WB positive control) 100 ug
$436.00

file-alt Citations

BMI1 regulates androgen receptor in prostate cancer independently of the polycomb repressive complex 1
Zhu, Zhao, Yan et al
Nat Commun (2018) 9 (1), 500 DOI: 10.1038/s41467-018-02863-3
AI Summary: OriGene’s purified His-BMI1 protein (TP760041) was used in this study to investigate the molecular interactions and functional role of BMI1 in regulating androgen receptor stability in prostate cancer cells.
Snippet: G (H+L)-HRP (SA001-500, GenDEPOT), or goat anti-rabbit IgG (H+L)-HRP (SA002-500, GenDEPOT). Purified 6×His AR-NTD protein was bought from Ray Bioteck (RB-14-0003P). Purified His-BMI1 was bought from ORIGENE (TP760041). The Glutathione Sepharose 4B (GST beads) (17-0756-01, GE Healthcare) was used for in vitro IP. RING1B siRNA (#1, s12067, or #2 s12068), MDM2 siRNA (#1, 58628 or #2, 58629), or BMI
FigureFigureFigure
BMI1, a new target of CK2α
Banerjee Mustafi, Chakraborty, Dwivedi et al
Mol. Cancer (2017) 16 (1), 56 DOI: 10.1186/s12943-017-0617-8
AI Summary: OriGene's full-length BMI1 recombinant protein (TP760041) was used in this study to investigate the phosphorylation and functional analysis of BMI1 as a target of CK2α.
Snippet: 90745) respectively. GST-tagged or full-length BMI1 recombinant proteins were purchased from Mybiosource.com (#MBS717171) and Origene (TP760041) respectively. GST was purchased from Abcam (#89499). Nonradioactive ... All 6 versions Cite SaveSaving
FigureFigureFigure
Showing 1-2 of 2 papers.
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