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GRM1 Human Recombinant Protein, Synthetic Nanodisc

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SKU
TP728780M
Recombinant Human GRM1 full length protein-Synthetic Nanodisc, 100 ug
Size:
100 ug 10 ug
  $10,375.00
8 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Tag C-Flag & Strep Tag
Predicted MW 132.4 kDa
Concentration Please refer to the Certificate of Analysis (COA) for the lot-specific concentration before lyophilization.
Buffer Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Storage Store at -20°C to -80°C for 12 months in lyophilized form.
Stability After reconstitution, if not intended for use within a month, aliquot and store at -80°C . Avoid repeated freezing and thawing.
Shipping Ambient
Reference Data
UniProt ID Q13255
Synonyms GPRC1A, MGLU1, MGLUR1, PPP1R85, SCA44, SCAR13
Summary This gene encodes a metabotropic glutamate receptor that functions by activating phospholipase C. L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The canonical alpha isoform of the encoded protein is a disulfide-linked homodimer whose activity is mediated by a G-protein-coupled phosphatidylinositol-calcium second messenger system. This gene may be associated with many disease states, including schizophrenia, bipolar disorder, depression, and breast cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, May 2013
Protein Categories GPCR, Membrane Proteins, Nervous system: Neurodegenerative diseases
Protein Families Druggable Genome, GPCR, Transmembrane
Protein Pathways GPCRDB Class C Metabotropic glutamate pheromone, GPCRDB Other
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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