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ACHD Human Recombinant Protein, Synthetic Nanodisc

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SKU
TP728575M
Recombinant Human ACHD full length protein-Synthetic Nanodisc, 100 ug
Size:
100 ug 10 ug
  $10,375.00
8 Weeks*
Bulk/Customize

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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Tag C-Flag & Strep Tag
Predicted MW 58.9 kDa
Concentration Please refer to the Certificate of Analysis (COA) for the lot-specific concentration before lyophilization.
Buffer Lyophilized from nanodisc solubilization buffer (20 mM Tris-HCl, 150 mM NaCl, pH 8.0). Normally 5% - 8% trehalose is added as protectants before lyophilization. Do not use solvents with pH lower than 6.5 in subsequent experiments.
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Storage Store at -20°C to -80°C for 12 months in lyophilized form.
Stability After reconstitution, if not intended for use within a month, aliquot and store at -80°C . Avoid repeated freezing and thawing.
Shipping Ambient
Reference Data
UniProt ID Q07001
Synonyms ACHRD, CMS2A, CMS3A, CMS3B, CMS3C, FCCMS, SCCMS
Summary This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. provided by RefSeq, Sep 2017
Protein Categories Intracellular Proteins, Membrane Proteins, Nervous system Diseases
Protein Families Ion Channels: Cys-loop Receptors
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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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