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TNFSF9 Human Recombinant Protein

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SKU
TP723968
Recombinant human 4-1BB Ligand Protein with N-terminal mouse Fc and C-terminal 6×His tag
Size:
100 ug
  $825.00
4 Weeks*
Bulk/Customize

Frequently Bought Together (1)

TA813213 CD137L mouse monoclonal antibody,clone OTI3B6 100 ul
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
mFc(Pro99-Lys330) 4-1BB Ligand(Pro52-Glu254) 6×His
Tag N-Mouse Fc and C-6×His Tag
Predicted MW The protein has a predicted molecular mass of 49.8 kDa after removal of the signal peptide.The apparent molecular mass of mFc-4-1BB Ligand-His is approximately 53-70 kDa due to glycosylation.
Purity The purity of the protein is greater than 95% as determined by SDS-PAGE and Coomassie blue staining.
Buffer Lyophilized from sterile PBS, pH 7.4. Normally 5% - 8% trehalose is added as protectants before lyophilization
Reconstitution Method 1. Before opening the tube cap, centrifuge the sample tube at 5000g for 3-5min at room temperature to ensure the lyophilized sample settles down at the bottom of the tube.
2. Calculate the volume for reconstitution (in µL) using the formula: Quantity (mg)/Concentration (mg/mL)x1000
3. Dissolve the lyophilized protein sample in sterile water based on the calculated volume (µL)
4. After adding sterile water, cover the lid and mix by gently tapping the tube 5-10 times. Note: Do not vortex or vigorously pipette the sample.
Preparation Affinity purification
Storage Store the lyophilized protein at -20°C.
After reconstitution, store the protein at -80°C for 12 months.
Avoid repeated freezing and thawing.
Stability 12 months from date of despatch
Shipping Ambient
Reference Data
Locus ID 8744
UniProt ID P41273
Synonyms 4-1BB Ligand;TNFSF9;CD137L
Summary The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.
Protein Categories Cytokines, Intracellular Proteins
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction
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Other "TNFSF9" proteins (6)
SKU Description Size Price
PH311160 TNFSF9 MS Standard C13 and N15-labeled recombinant protein (NP_003802) 10 ug
$3,360.00
LC418412 Lyophilized TNFSF9 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY418412 Transient overexpression lysate of tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9) (as WB positive control) 100 ug
$436.00
TP311160 Recombinant protein of human tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9), 20 µg 20 ug
$737.00
TP700282 Purified recombinant protein of human tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9), with C-terminal Fc tag, expressed in human cells, 20 µg 20 ug
$900.00
TP721145 Purified recombinant protein of Human tumor necrosis factor (ligand) superfamily, member 9 (TNFSF9) 10 ug
$275.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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