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CD40 (NM_001250) Human Recombinant Protein

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SKU
TP720633
Purified recombinant protein of Human CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 1
Size:
10 ug 500 ug 50 ug 1 mg
  $190.00
5 Days*
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Frequently Bought Together (1)

TA807575 CD40 mouse monoclonal antibody, clone OTI1F12 (formerly 1F12) 100 ul
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Specifications
Specifications
Product Data
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence
Protein Sequence
Glu21-Arg193
Tag C-His
Predicted MW 20.2 kDa
Concentration lot specific
Purity >95% as determined by SDS-PAGE and Coomassie blue staining
Buffer Lyophilized from a 0.2 um filtered solution of 20mM PB, 150mM NaCl, pH 7.4.
Endotoxin Endotoxin level is < 0.1 ng/µg of protein (< 1 EU/µg)
Reconstitution Method Always centrifuge tubes before opening. Do not mix by vortex or pipetting. Dissolve the lyophilized protein in ddH2O. It is not recommended to reconstitute a concentration less than 100 µg/ml. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
Storage Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Stability Stable for at least 6 months from date of receipt under proper storage and handling conditions.
Shipping Ambient
Reference Data
RefSeq NP_001241
Locus ID 958
UniProt ID P25942
Cytogenetics 20q13.12
RefSeq Size 1616
RefSeq ORF 831
Synonyms Bp50; CDW40; p50; TNFRSF5
Summary This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. provided by RefSeq, Nov 2014
Protein Categories ADC Targets, CD Markers, Immune system diseases, Membrane Proteins, Secreated Proteins
Protein Families Druggable Genome, Secreted Protein, Transmembrane
Protein Pathways Allograft rejection, Asthma, Autoimmune thyroid disease, Cell adhesion molecules (CAMs), Cytokine-cytokine receptor interaction, Primary immunodeficiency, Systemic lupus erythematosus, Toll-like receptor signaling pathway, Viral myocarditis
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Other "CD40" proteins (5)
SKU Description Size Price
LC400500 Lyophilized CD40 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LC407183 Lyophilized CD40 HEK293T cell transient overexpression lysate (as WB positive control) 20 ug
$206.00
LY400500 Transient overexpression lysate of CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 1 (as WB positive control) 100 ug
$436.00
LY407183 Transient overexpression lysate of CD40 molecule, TNF receptor superfamily member 5 (CD40), transcript variant 2 (as WB positive control) 100 ug
$436.00
TP723938 Recombinant human CD40 protein with C-terminal mouse Fc and 6×His tag 100 ug
$795.00

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*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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