P Glycoprotein(ABCB1) (NM_000927) Human Recombinant Protein

CAT#: TP710110

Recombinant protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), residues 347-710aa,with C-terminal DDK tag,expressed in sf9 cells

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 Product Datasheet for 'TP710110'

USD 399.00


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    • 20 ug

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Specifications

Product Data
Description Recombinant protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), residues 347-710aa,with C-terminal DDK tag,expressed in sf9 cells
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC216080, encoding the region(Met-Gln347-Tyr710) of Homo sapiens ABCB1
Tag C-HIS
Predicted MW 41 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol. Store at -80C. Avoid repeated freeze-thaw cycles. Stable for at least 3 months from receipt of products under proper storage and handling conditions.
Reference Data
RefSeq NP_000918
Locus ID 5243
Refseq Size 4872
Cytogenetics 7q21.12
Refseq ORF 3840
Synonyms ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. [provided by RefSeq, Jul 2008].
Protein Families
Protein Pathways
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