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P Glycoprotein (ABCB1) (NM_000927) Human Recombinant Protein

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SKU
TP710110
Recombinant protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), residues 347-710aa,with C-terminal DDK tag,expressed in sf9 cells
Size:
20 ug
  $540.00
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Specifications
Specifications
Product Data
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence
Protein Sequence
A DNA sequence from TrueORF clone, RC216080, encoding the region(Met-Gln347-Tyr710) of Homo sapiens ABCB1
Tag C-DDK
Predicted MW 41 kDa
Concentration >0.05 µg/µL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50 mM Tris-HCl, 100 mM glycine, pH 8.0, 10% glycerol
Note For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process.
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Shipping Dry Ice
Reference Data
RefSeq NP_000918
Locus ID 5243
UniProt ID P08183
Cytogenetics 7q21.12
RefSeq Size 4872
RefSeq ORF 3840
Synonyms ABC20; CD243; CLCS; GP170; MDR1; p-170; P-GP; PGY1
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. provided by RefSeq, Feb 2017
Protein Categories CD Markers, Immune system diseases, Intracellular Proteins, Membrane Proteins
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways ABC transporters
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Documents
Resources
Other "P Glycoprotein" proteins (3)
SKU Description Size Price
TP710111 Recombinant protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), residues 995-1280aa,with C-terminal DDK tag,expressed in sf9 cells 20 ug
$540.00
TP762264 Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), Gln347-Tyr710, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$260.00
TP762415 Purified recombinant protein of Human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), Met1-Tyr50-GGGGS-Gly600-Ile700, with N-terminal His tag, expressed in E.coli, 50ug 50 ug
$260.00

file-alt Citations

Profiling antibody signature of schizophrenia by Escherichia coli proteome microarrays
Chen, Hsu, Chen et al
Brain, Behavior, and Immunity (2022) 106, 11-20 DOI: 10.1016/j.bbi.2022.07.162
Cited by 13
AI Summary: OriGene's ABCB1 protein (catalog number TP710110) was used to create microarray chips for detecting ABCB1 autoantibodies, enabling the study to identify elevated ABCB1 autoantibody levels in adult-onset schizophrenia patients.
Snippet: … If the symptoms express after adolescence, Save;Twenty µg/ml of ABCB1 protein (TP710110;OriGene Technologies, Rockville, MD) was printed on an aldehyde-functional glass slide by a SmartArrayer 48TM Microarray Spotter (Capital Bio, Beijing) for immobilizing the ABCB1 autoantibody identification chip
Showing 1-1 of 1 papers.
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