P Glycoprotein (ABCB1) (NM_000927) Human Recombinant Protein

CAT#: TP710110

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Recombinant protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), residues 347-710aa,with C-terminal DDK tag,expressed in sf9 cells


Product Datasheet for 'TP710110'


  View other "ABCB1" proteins (2)

USD 425.00


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    • 20 ug


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Product Data
Description Recombinant protein of human ATP-binding cassette, sub-family B (MDR/TAP), member 1 (ABCB1), residues 347-710aa,with C-terminal DDK tag,expressed in sf9 cells
Species Human
Expression Host Sf9
Expression cDNA Clone or AA Sequence A DNA sequence from TrueORF clone, RC216080, encoding the region(Met-Gln347-Tyr710) of Homo sapiens ABCB1
Tag C-His
Predicted MW 41 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 50mM Tris-HCl, pH8.0, 100mM glycine, 10% glycerol
Storage Store at -80°C.
Stability Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Reference Data
RefSeq NP_000918
Locus ID 5243
Refseq Size 4872
Cytogenetics 7q21.12
Refseq ORF 3840
Synonyms ABC20; CD243; CLCS; GP170; MDR1; P-GP; PGY1
Summary The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017]
Protein Families Druggable Genome, ES Cell Differentiation/IPS, Transmembrane
Protein Pathways ABC transporters

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