TDP43 (TARDBP) (NM_007375) Human Recombinant Protein
SKU
TP710010
Recombinant protein of human TAR DNA binding protein (TARDBP), full length, with C-terminal DDK tag,expressed in sf9 cells
$540.00
In Stock*
Specifications
| Product Data | |
| Species | Human |
|---|---|
| Expression Host | Sf9 |
| Expression cDNA Clone or AA Sequence | |
| Tag | C-DDK |
| Predicted MW | 45 kDa |
| Concentration | >0.05 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 50 mM Tris-HCl, pH 8.0, 150 mM NaCl, 20% glycerol |
| Bioactivity | In vitro splicing assay regulator (PMID: 29562314) |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Shipping | Dry Ice |
| Reference Data | |
| RefSeq | NP_007366 |
| Locus ID | 23435 |
| UniProt ID | Q13148 |
| Cytogenetics | 1p36.22 |
| RefSeq Size | 4236 |
| RefSeq ORF | 1242 |
| Synonyms | ALS10; TDP-43 |
| Summary | HIV-1, the causative agent of acquired immunodeficiency syndrome (AIDS), contains an RNA genome that produces a chromosomally integrated DNA during the replicative cycle. Activation of HIV-1 gene expression by the transactivator Tat is dependent on an RNA regulatory element (TAR) located downstream of the transcription initiation site. The protein encoded by this gene is a transcriptional repressor that binds to chromosomally integrated TAR DNA and represses HIV-1 transcription. In addition, this protein regulates alternate splicing of the CFTR gene. A similar pseudogene is present on chromosome 20. provided by RefSeq, Jul 2008 |
| Protein Categories | Intracellular Proteins, Nervous system: Neurodegenerative diseases |
| Protein Families | Transcription Factors |
Reviews
Documents
| FAQs |
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Resources
| Recombinant Protein Resources |
Other "TDP43" proteins (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| PH310639 | TARDBP MS Standard C13 and N15-labeled recombinant protein (NP_031401) | 10 ug |
$3,360.00
|
|
| LC402137 | Lyophilized TARDBP HEK293T cell transient overexpression lysate (as WB positive control) | 20 ug |
$206.00
|
|
| LY402137 | Transient overexpression lysate of TAR DNA binding protein (TARDBP) (as WB positive control) | 100 ug |
$436.00
|
|
| TP310639 | Recombinant protein of human TAR DNA binding protein (TARDBP), 20 µg | 20 ug |
$867.00
|
|
Citations
Location and function of TDP-43 in platelets, alterations in neurodegenerative diseases and arising considerations for current plasma biobank protocols
Luthi-Carter, Cappelli, Le Roux-Bourdieu et al
Sci Rep (2024) 14 (1), 21837 DOI: 10.1038/s41598-024-70822-8
Luthi-Carter, Cappelli, Le Roux-Bourdieu et al
Sci Rep (2024) 14 (1), 21837 DOI: 10.1038/s41598-024-70822-8
Cited by 10
AI Summary: OriGene’s recombinant TDP-43 protein (Cat #TP710010) was used to generate standard curves for quantifying TDP-43 concentrations in plasma and platelet samples, enabling the development and validation of novel immunoassays in this study.
Snippet: he resulting signal was measured using a MESO QuickPlex SQ 120 instrument. A standard curve was generated by plotting the signal intensities of the known concentrations of recombinant TDP-43 protein (Origene, Cat #TP710010). The concentrations of TDP-43 in the samples were interpolated from the standard curve using the corresponding signal intensities. Further description of assay development and
TDP-43 regulates the alternative splicing of hnRNP A1 to yield an aggregation-prone variant in amyotrophic lateral sclerosis
Deshaies, Shkreta, Moszczynski et al
Brain (2018)
Deshaies, Shkreta, Moszczynski et al
Brain (2018)
AI Summary: In this study, the OriGene recombinant TDP-43 protein (TP710010) was used to investigate how TDP-43 regulates the alternative splicing of hnRNP A1, contributing to the understanding of protein aggregation in amyotrophic lateral sclerosis.
Snippet: See Fratta and Isaacs (doi:10.1093/brain/awy091) for a scientific commentary on this article.Mutations in the RNA binding proteins TDP-43 and hnRNP A1 are assoc.;... al._, 1983) and incubated with hnRNP A1 7B pre-mRNA (Blanchette, 1999) and a competing oligo (TG)13 or a non-targeting control oligo 5′-TCGCAGCAAACTCCGGCACTT-3′;or recombinant TDP-43 (TP710010, Origene) for 2 h at 30°C. …
Dual vulnerability of TDP-43 to calpain and caspase-3 proteolysis after neurotoxic conditions and traumatic brain injury
Yang, Lin, Robertson et al
J. Cereb. Blood Flow Metab. (2014)
Yang, Lin, Robertson et al
J. Cereb. Blood Flow Metab. (2014)
Cited by 76
AI Summary: OriGene’s purified recombinant human TDP-43 protein was used in in vitro protease digestion experiments to map TDP-43 fragmentation patterns, helping elucidate its vulnerability to calpain and caspase-3 after neurotoxic conditions and traumatic brain injury.
Snippet: In vitro digestion of cortex lysate (100 μg) or purified recombinant human TDP-43 protein (3 μg, OriGene, MD, USA) was performed with human erythrocyte calpain-1 (Calbiochem/EMD Bioscience, Billerica, MA, USA) and human recombinant caspase-3 (BD ... Cite SaveSaving
Showing 1-3 of 3 papers.
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