NRAS (NM_002524) Human Recombinant Protein

CAT#: TP701004

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Purified recombinant protein of Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mutant (Q61K), expressed in HEK293 cells, 20ug


 Product Datasheet for 'TP701004'

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USD 748.00


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    • 20 ug


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Product Data
Description Purified recombinant protein of Homo sapiens neuroblastoma RAS viral (v-ras) oncogene homolog (NRAS), mutant (Q61K), expressed in HEK293 cells, 20ug
Species Human
Expression Host HEK293
Tag C-Myc/DDK
Predicted MW 21 kDa
Concentration >50 ug/mL as determined by microplate BCA method
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Buffer 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol
Reference Data
RefSeq NP_002515
Locus ID 4893
Refseq Size 4461
Cytogenetics 1p13.2
Refseq ORF 569
Synonyms ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6
Summary This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. [provided by RefSeq, Jun 2011]
Protein Families Druggable Genome
Protein Pathways Acute myeloid leukemia, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Thyroid cancer, Tight junction, VEGF signaling pathway

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