NRAS Mouse Monoclonal Antibody [Clone ID: OTI5G7]
$447.00
In Stock*
Specifications
| Product Data | |
| Clone Name | OTI5G7 |
|---|---|
| Application | IHC, WB |
| Recommended Dilution | WB 1:2000, IHC 1:150 |
| Reactivity | Human, Mouse, Rat |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Full length human recombinant protein of human NRAS (NP_002515) produced in HEK293T cell. |
| Buffer | PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide |
| Concentration | 1 mg/ml |
| Purification | Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G) |
| Conjugation | Unconjugated |
| Storage | Store at -20°C as received. |
| Stability | Stable for 12 months from date of receipt. |
| Shipping | Blue Ice |
| Predicted Protein Size | 21 kDa |
| Gene Name | NRAS proto-oncogene, GTPase |
| Database Link | |
| Background | This is an N-ras oncogene encoding a membrane protein that shuttles between the Golgi apparatus and the plasma membrane. This shuttling is regulated through palmitoylation and depalmitoylation by the ZDHHC9-GOLGA7 complex. The encoded protein, which has intrinsic GTPase activity, is activated by a guanine nucleotide-exchange factor and inactivated by a GTPase activating protein. Mutations in this gene have been associated with somatic rectal cancer, follicular thyroid cancer, autoimmune lymphoproliferative syndrome, Noonan syndrome, and juvenile myelomonocytic leukemia. provided by RefSeq, Jun 2011 |
| Synonyms | ALPS4; CMNS; N-ras; NCMS; NRAS1; NS6 |
| Reference Data | |
| Protein Categories | Cancer: Endocrine, Cancer: Gastrointestinal, Cancer: Haematopoietic and Lymphoid, Cancer: Head and Neck, Cancer: Sarcoma, Cancer: Skin, Cardiovascular diseases, Immune system diseases, Intracellular Proteins |
| Protein Families | Druggable Genome |
| Protein Pathways | Acute myeloid leukemia, Axon guidance, B cell receptor signaling pathway, Bladder cancer, Chemokine signaling pathway, Chronic myeloid leukemia, Endometrial cancer, ErbB signaling pathway, Fc epsilon RI signaling pathway, Gap junction, Glioma, GnRH signaling pathway, Insulin signaling pathway, Long-term depression, Long-term potentiation, MAPK signaling pathway, Melanogenesis, Melanoma, Natural killer cell mediated cytotoxicity, Neurotrophin signaling pathway, Non-small cell lung cancer, Pathways in cancer, Prostate cancer, Regulation of actin cytoskeleton, Renal cell carcinoma, T cell receptor signaling pathway, Thyroid cancer, Tight junction, VEGF signaling pathway |
Reviews
Documents
| Product Manuals |
| FAQs |
| SDS |
Resources
Other "OTI5G7" antibodies (4)
| SKU | Description | Size | Price | |
|---|---|---|---|---|
| CF505835 | Carrier-free (BSA/glycerol-free) NRAS mouse monoclonal antibody, clone OTI5G7 (formerly 5G7) | 100 ug |
$620.00
|
|
| TA505835AM | NRAS mouse monoclonal antibody,clone 5G7, Biotinylated | 100 ul |
$509.00
|
|
| TA505835BM | NRAS mouse monoclonal antibody,clone 5G7, HRP conjugated | 100 ul |
$509.00
|
|
| TA505835S | NRAS mouse monoclonal antibody, clone OTI5G7 (formerly 5G7) | 30 ul |
$200.00
|
|
Citations
Usp9x regulates Ets-1 ubiquitination and stability to control NRAS expression and tumorigenicity in melanoma
Potu, Peterson, Kandarpa et al
Nat Commun (2017) 8, 14449 DOI: 10.1038/ncomms14449
Potu, Peterson, Kandarpa et al
Nat Commun (2017) 8, 14449 DOI: 10.1038/ncomms14449
AI Summary: OriGene’s NRAS antibody (clone 5G7) was used for immunohistochemistry to assess NRAS protein levels in melanoma tissue samples, contributing to the study’s analysis of the Usp9x/Ets-1/NRAS regulatory network.
Snippet: Tumour content of each core or slide was verified by H&E staining. Immunohistochemistry was performed using anti-Usp9x (1:1,000, Abcam), Ets-1 (1:500, Bethyl) and NRAS (1:150, Origene, clone 5G7)
Showing 1-1 of 1 papers.
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